Investigating the thermal behavior of doxycycline and meclocycline

The thermal behavior of the antibiotics doxycycline (Dox) and meclocycline (Meclo) in the monohydrate and sulfosalicylate forms was investigated by TG/DTG, TG/DTA, DSC and TG-FTIR. Dox decomposed in three steps after its melting at 174 °C, with no evidence of crystallization on cooling. According to...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2022-12, Vol.147 (23), p.13413-13423
Main Authors: de Freitas, Jonatha, Ferreira, Ana P. G., Cavalheiro, Éder T. G.
Format: Article
Language:English
Subjects:
Ammonia
Analysis
Analytical Chemistry
Antibiotics
Carbon dioxide
Carbon monoxide
Chemistry
Chemistry and Materials Science
Crystallization
Differential thermal analysis
Doxycycline
Gas analysis
Inorganic Chemistry
Investigations
Measurement Science and Instrumentation
Meclocycline
Methane
Physical Chemistry
Polymer Sciences
Sulfur dioxide
Thermal decomposition
Thermal degradation
Thermodynamic properties
Thermogravimetry
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Summary:The thermal behavior of the antibiotics doxycycline (Dox) and meclocycline (Meclo) in the monohydrate and sulfosalicylate forms was investigated by TG/DTG, TG/DTA, DSC and TG-FTIR. Dox decomposed in three steps after its melting at 174 °C, with no evidence of crystallization on cooling. According to thermogravimetry associated with evolved gas analysis, it was suggested that decomposition begins with the release of: water, isocyanic acid, dimethylamine, as well as carbon dioxide and ammonia, resulting from the decomposition of isocyanic acid. At 535 °C carbon monoxide, methane and water were identified in gaseous phase. Meclo decomposed in two steps and did not presented melting and crystallization events. The gases released by Meclo during thermal decomposition were sulfur dioxide (from sulfosalicylate), carbon dioxide, isocyanic acid, carbon monoxide and ammonia. A mechanism for the thermal degradation of both antibiotics in nitrogen, has been proposed.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-022-11596-x