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Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes
This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, p...
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| Published in: | Archives of women's mental health 2022-12, Vol.25 (6), p.1097-1104 |
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| container_title | Archives of women's mental health |
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| creator | Klasner, Carson Brown, Jessica Gopalakrishnan, Mathangi Metwally, Dina El Besse, Margaret Mark, Katrina |
| description | This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, prenatal care metrics, and birth statistics. Multivariable logistic regression analysis was performed to assess the relationship between ACE score, cannabis use, and pregnancy outcomes. Of 256 birth parents, 87 (34.0%) tested positive for cannabis at initial visit and 39 (15.2%) tested positive for cannabis at delivery. Testing positive for cannabis at initial visit or delivery was associated with higher ACE score (15.1 vs 13.7,
p
= 0.04; 16.2 vs 13.8,
p
= 0.01). Of those who tested positive for cannabis at initial visit, 39/87 (45.0%) tested positive at delivery. Continued cannabis use at delivery was associated with lower maternal weight gain (7.9 kg vs 13.3 kg,
p
= 0.003), fewer prenatal visits (7 vs 8,
p
= 0.010), and numerically higher mean ACE score. Cannabis use at delivery was associated with 10% lower birthweight (2665 g vs 3014 g
p
|
| doi_str_mv | 10.1007/s00737-022-01269-x |
| format | article |
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p
= 0.04; 16.2 vs 13.8,
p
= 0.01). Of those who tested positive for cannabis at initial visit, 39/87 (45.0%) tested positive at delivery. Continued cannabis use at delivery was associated with lower maternal weight gain (7.9 kg vs 13.3 kg,
p
= 0.003), fewer prenatal visits (7 vs 8,
p
= 0.010), and numerically higher mean ACE score. Cannabis use at delivery was associated with 10% lower birthweight (2665 g vs 3014 g
p
< 0.05) but not with pre-term birth. Total ACE score was not significantly associated with any birth outcome. Worse pregnancy outcomes were associated with cannabis use throughout pregnancy but not with cannabis use at prenatal care initiation. The interplay of ACE and continued cannabis use during pregnancy warrants further research on the physiologic effects of cannabis and interventions to decrease substance use during pregnancy.</description><identifier>ISSN: 1434-1816</identifier><identifier>EISSN: 1435-1102</identifier><identifier>DOI: 10.1007/s00737-022-01269-x</identifier><identifier>PMID: 36203114</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adverse Childhood Experiences ; Birth Weight ; Cannabis ; Cannabis - adverse effects ; Child abuse & neglect ; Childbirth & labor ; Childhood ; Childhood factors ; Children ; Drug abuse in pregnancy ; Female ; Forecasts and trends ; Health aspects ; Humans ; Infant, Newborn ; Marijuana ; Medicine ; Medicine & Public Health ; Mental health ; Mothers ; Original Article ; Parents & parenting ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pregnancy, Complications of ; Prenatal Care ; Psychiatry ; Psychotherapy ; Statistical analysis ; Substance abuse ; Substance use ; Womens health</subject><ispartof>Archives of women's mental health, 2022-12, Vol.25 (6), p.1097-1104</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-d40f67507e7d1e8126d454689f60a6eb93f0c09b0e2e6b015fc01e157271a0b3</citedby><cites>FETCH-LOGICAL-c442t-d40f67507e7d1e8126d454689f60a6eb93f0c09b0e2e6b015fc01e157271a0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27321,27901,27902,33751</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36203114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klasner, Carson</creatorcontrib><creatorcontrib>Brown, Jessica</creatorcontrib><creatorcontrib>Gopalakrishnan, Mathangi</creatorcontrib><creatorcontrib>Metwally, Dina El</creatorcontrib><creatorcontrib>Besse, Margaret</creatorcontrib><creatorcontrib>Mark, Katrina</creatorcontrib><title>Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes</title><title>Archives of women's mental health</title><addtitle>Arch Womens Ment Health</addtitle><addtitle>Arch Womens Ment Health</addtitle><description>This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, prenatal care metrics, and birth statistics. Multivariable logistic regression analysis was performed to assess the relationship between ACE score, cannabis use, and pregnancy outcomes. Of 256 birth parents, 87 (34.0%) tested positive for cannabis at initial visit and 39 (15.2%) tested positive for cannabis at delivery. Testing positive for cannabis at initial visit or delivery was associated with higher ACE score (15.1 vs 13.7,
p
= 0.04; 16.2 vs 13.8,
p
= 0.01). Of those who tested positive for cannabis at initial visit, 39/87 (45.0%) tested positive at delivery. Continued cannabis use at delivery was associated with lower maternal weight gain (7.9 kg vs 13.3 kg,
p
= 0.003), fewer prenatal visits (7 vs 8,
p
= 0.010), and numerically higher mean ACE score. Cannabis use at delivery was associated with 10% lower birthweight (2665 g vs 3014 g
p
< 0.05) but not with pre-term birth. Total ACE score was not significantly associated with any birth outcome. Worse pregnancy outcomes were associated with cannabis use throughout pregnancy but not with cannabis use at prenatal care initiation. The interplay of ACE and continued cannabis use during pregnancy warrants further research on the physiologic effects of cannabis and interventions to decrease substance use during pregnancy.</description><subject>Adverse Childhood Experiences</subject><subject>Birth Weight</subject><subject>Cannabis</subject><subject>Cannabis - adverse effects</subject><subject>Child abuse & neglect</subject><subject>Childbirth & labor</subject><subject>Childhood</subject><subject>Childhood factors</subject><subject>Children</subject><subject>Drug abuse in pregnancy</subject><subject>Female</subject><subject>Forecasts and trends</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Marijuana</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental health</subject><subject>Mothers</subject><subject>Original Article</subject><subject>Parents & parenting</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy, Complications of</subject><subject>Prenatal Care</subject><subject>Psychiatry</subject><subject>Psychotherapy</subject><subject>Statistical analysis</subject><subject>Substance abuse</subject><subject>Substance use</subject><subject>Womens health</subject><issn>1434-1816</issn><issn>1435-1102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BHHNA</sourceid><recordid>eNp9kV1rHCEYhaU0NB_tH-hFEXrTXkz6-jG6c7ks26YQyE1uizj6upmwo1udKZt_H5NNGwohCPqizzl4OIR8ZHDOAPS3UjehG-C8AcZV1-zfkBMmRdswBvzt4ywbtmDqmJyWcgsAbdfJd-RYKA6CMXlCfq1DQDfRFOhoJ8zRbqn1fzAXpO5m2PqblDzF_Q7zgNFhoV-Wq_VXaqOnzsZo-6HQucIp0l3GTbTR3dE0Ty6NWN6To2C3BT88nWfk-vv6enXRXF79-LlaXjZOSj41XkJQugWN2jNc1CxetlItuqDAKuw7EcBB1wNyVD2wNjhgyFrNNbPQizPy-WC7y-n3jGUyt2l-iFIM13KhRLXmz9TGbtEMMaQpWzcOxZml5l3bqlZApc5foOryOA4uRQxDvf9PwA8Cl1MpGYPZ5WG0-c4wMA89mUNPpvZkHnsy-yr69PTjuR_R_5P8LaYC4gCU-hQ3mJ8jvWJ7D22vm6I</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Klasner, Carson</creator><creator>Brown, Jessica</creator><creator>Gopalakrishnan, Mathangi</creator><creator>Metwally, Dina El</creator><creator>Besse, Margaret</creator><creator>Mark, Katrina</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7R6</scope><scope>7TK</scope><scope>7U3</scope><scope>7X7</scope><scope>7XB</scope><scope>888</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHHNA</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQGEN</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>QXPDG</scope></search><sort><creationdate>20221201</creationdate><title>Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes</title><author>Klasner, Carson ; Brown, Jessica ; Gopalakrishnan, Mathangi ; Metwally, Dina El ; Besse, Margaret ; Mark, Katrina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-d40f67507e7d1e8126d454689f60a6eb93f0c09b0e2e6b015fc01e157271a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adverse Childhood Experiences</topic><topic>Birth Weight</topic><topic>Cannabis</topic><topic>Cannabis - adverse effects</topic><topic>Child abuse & neglect</topic><topic>Childbirth & labor</topic><topic>Childhood</topic><topic>Childhood factors</topic><topic>Children</topic><topic>Drug abuse in pregnancy</topic><topic>Female</topic><topic>Forecasts and trends</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Marijuana</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental health</topic><topic>Mothers</topic><topic>Original Article</topic><topic>Parents & parenting</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy, Complications of</topic><topic>Prenatal Care</topic><topic>Psychiatry</topic><topic>Psychotherapy</topic><topic>Statistical analysis</topic><topic>Substance abuse</topic><topic>Substance use</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klasner, Carson</creatorcontrib><creatorcontrib>Brown, Jessica</creatorcontrib><creatorcontrib>Gopalakrishnan, Mathangi</creatorcontrib><creatorcontrib>Metwally, Dina El</creatorcontrib><creatorcontrib>Besse, Margaret</creatorcontrib><creatorcontrib>Mark, Katrina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>GenderWatch</collection><collection>Neurosciences Abstracts</collection><collection>Social Services Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>GenderWatch (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Sociological Abstracts</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest Women's & Gender Studies</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Diversity Collection</collection><jtitle>Archives of women's mental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klasner, Carson</au><au>Brown, Jessica</au><au>Gopalakrishnan, Mathangi</au><au>Metwally, Dina El</au><au>Besse, Margaret</au><au>Mark, Katrina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes</atitle><jtitle>Archives of women's mental health</jtitle><stitle>Arch Womens Ment Health</stitle><addtitle>Arch Womens Ment Health</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>25</volume><issue>6</issue><spage>1097</spage><epage>1104</epage><pages>1097-1104</pages><issn>1434-1816</issn><eissn>1435-1102</eissn><abstract>This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, prenatal care metrics, and birth statistics. Multivariable logistic regression analysis was performed to assess the relationship between ACE score, cannabis use, and pregnancy outcomes. Of 256 birth parents, 87 (34.0%) tested positive for cannabis at initial visit and 39 (15.2%) tested positive for cannabis at delivery. Testing positive for cannabis at initial visit or delivery was associated with higher ACE score (15.1 vs 13.7,
p
= 0.04; 16.2 vs 13.8,
p
= 0.01). Of those who tested positive for cannabis at initial visit, 39/87 (45.0%) tested positive at delivery. Continued cannabis use at delivery was associated with lower maternal weight gain (7.9 kg vs 13.3 kg,
p
= 0.003), fewer prenatal visits (7 vs 8,
p
= 0.010), and numerically higher mean ACE score. Cannabis use at delivery was associated with 10% lower birthweight (2665 g vs 3014 g
p
< 0.05) but not with pre-term birth. Total ACE score was not significantly associated with any birth outcome. Worse pregnancy outcomes were associated with cannabis use throughout pregnancy but not with cannabis use at prenatal care initiation. The interplay of ACE and continued cannabis use during pregnancy warrants further research on the physiologic effects of cannabis and interventions to decrease substance use during pregnancy.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>36203114</pmid><doi>10.1007/s00737-022-01269-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of women's mental health, 2022-12, Vol.25 (6), p.1097-1104 |
| issn | 1434-1816 1435-1102 |
| language | eng |
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| source | Springer Nature; Sociological Abstracts |
| subjects | Adverse Childhood Experiences Birth Weight Cannabis Cannabis - adverse effects Child abuse & neglect Childbirth & labor Childhood Childhood factors Children Drug abuse in pregnancy Female Forecasts and trends Health aspects Humans Infant, Newborn Marijuana Medicine Medicine & Public Health Mental health Mothers Original Article Parents & parenting Pregnancy Pregnancy Outcome - epidemiology Pregnancy, Complications of Prenatal Care Psychiatry Psychotherapy Statistical analysis Substance abuse Substance use Womens health |
| title | Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes |
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