Iodine Promoted Synthesis of S‐Benzoazolyl Chromones by a Three‐Component One‐Pot Reaction

In the presence of iodine, the synthesis of S‐benzoazolyl chromone derivatives by one‐pot manner is reported. Thus, 2‐aminophenol firstly reacted with tetramethylthiuram disulfide (TMTD) to form 2‐mercaptobenzoxazole, and then coupled with 2‐hydroxyphenyl enaminones to obtain S‐benzoazolyl chromones...

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Bibliographic Details
Published in:European journal of organic chemistry 2022-12, Vol.2022 (46), p.n/a
Main Authors: Jiang, Xin‐Yi, Wang, Xi, Yang, Cheng‐Li, Dong, Zhi‐Bing
Format: Article
Language:English
Subjects:
Aminophenol
Iodine
One-pot
Substrates
Sulfenylated chromone
Synthesis
Transition-metal-free
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Summary:In the presence of iodine, the synthesis of S‐benzoazolyl chromone derivatives by one‐pot manner is reported. Thus, 2‐aminophenol firstly reacted with tetramethylthiuram disulfide (TMTD) to form 2‐mercaptobenzoxazole, and then coupled with 2‐hydroxyphenyl enaminones to obtain S‐benzoazolyl chromones through one‐pot manner. This method features mild conditions, easy operation, environmentally friendliness and wide substrate scopes, illustrating practical application value in organic synthesis. A practical approach for the synthesis of S‐benzoazolyl chromones was reported. Using iodine as oxidant, 2‐hydroxyphenyl enaminones, tetramethylthiuram disulfide and 2‐aminophenol as starting materials, various S‐benzoazolyl chromones could be obtained by a one‐pot manner.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202201196