Clinical Associations of Metabolic Syndrome for Osteoporosis: Retrospective Cohort Study

• Published in: Obesity (Silver Spring, Md.) Md.), 2022-11, Vol.30, p.246-246
• Main Authors: Yu, Sung, Hong, Sangmo, Lee, Chang Beom, Lee, Kiyoung, Park, Jung, Kang, Jun Goo, Han, Byoungduck
• Format: Article
• Language: English
• Subjects: Cohort analysis; Medical screening; Metabolic syndrome; Obesity; Osteoporosis
• ISSN: 1930-7381; 1930-739X

Background: This study aimed to determine the prevalence and incidence of osteoporosis and osteoporotic vertebral fracture (OVF) in Korea and investigate whether metabolic syndrome (MS) status affects the prevalence of osteoporosis. Methods: We used data from the Health Insurance Review and Assessment Service (HIRA) claims and National Health Screening Examination (NHSE) database from January to December 2009. Results: A total of 8,674,118 subjects were included from the 2009 HIRA database. MS was more common in men than in women (71.76% vs. 59.91%, p < 0.0001). MS was found to increase the risk of osteoporosis in Koreans (osteoporosis with MS vs. osteoporosis without MS; 14.96% vs. 10.33%, p < 0.0001). After adjustment for age, sex, smoking, drinking, physical activity, income, MS increased the hazard ratio (HR) of osteoporosis in men [HR (95% CI);1.13 (1.117-1.144)]. But MS decreased the HR of osteoporosis in women [HR (95% CI);0.941 (0.934-0.948)]. Obesity increased the incidence of osteoporosis only in women with or without MS. Conclusions: MS increases the prevalence of osteoporosis in Korean men but decreases it in Korean women. In men, obesity does not affect the prevalence of osteoporosis; in contrast, in women, obesity increases the prevalence of osteoporosis.