Modulation of tumor‐associated macrophages in colitis‐associated colorectal cancer

Intestinal macrophages are the most abundant immune cells in the small and large intestine, which maintain intestinal homeostasis by clearing invading bacteria and dead cells, secreting anti‐inflammatory cytokines, and inducing tolerance to symbiotic bacteria and food particles. In addition, as anti...

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Bibliographic Details
Published in:Journal of cellular physiology 2022-12, Vol.237 (12), p.4443-4459
Main Authors: Dong, Yingjie, Yang, Qiuli, Niu, Ruiying, Zhang, Zhiyuan, Huang, Yijin, Bi, Yujing, Liu, Guangwei
Format: Article
Language:English
Subjects:
Antigen-presenting cells
Antigens
Apoptosis
Bacteria
cancer
Carcinogenesis
Carcinogens
Colitis
Colitis-Associated Neoplasms
colitis‐associated colorectal cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - pathology
Cytokines
Epithelial cells
Epithelium
Homeostasis
Humans
Immune response
Immune system
Immunity, Innate
Immunological tolerance
Inflammation
Inflammation - pathology
Inflammatory bowel disease
Innate immunity
Intestine
Large intestine
Macrophages
Tumor cells
Tumor Microenvironment
Tumor-Associated Macrophages - pathology
Tumors
tumor‐associated macrophages
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Summary:Intestinal macrophages are the most abundant immune cells in the small and large intestine, which maintain intestinal homeostasis by clearing invading bacteria and dead cells, secreting anti‐inflammatory cytokines, and inducing tolerance to symbiotic bacteria and food particles. In addition, as antigen‐presenting cells, they also participate in eliciting adaptive immune responses through bridging innate immune responses. After the intestinal homeostasis is disrupted, the damaged or apoptotic intestinal epithelial cells cannot be effectively cleared, and the infection of exogenous pathogens and leakage of endogenous antigens lead to persistent intestinal inflammation. Long‐term chronic inflammation is one of the important causes of colitis‐associated carcinogenesis (CAC). Tumor microenvironment (TME) is gradually formed around tumor cells, in which tumor associated macrophage (TAMs) is not only the builder, but also regulated by TME. This review just briefly summarized the role of intestinal macrophages under physiological and pathological inflammatory and cancerous conditions, and current therapeutic strategies for intestinal diseases targeting macrophages.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.30906