Association of sleep duration and sleep quality with the risk of metabolic syndrome in adults: a systematic review and meta-analysis

• Published in: Endokrynologia polska 2022-01, Vol.73 (6), p.968-987
• Main Authors: Hu, Jingyao, Zhu, Xiaoyue, Yuan, Defu, Ji, Dakang, Guo, Haijian, Li, You, He, Zhiliang, Bai, Hexiang, Zhu, Qiuqi, Shen, Chenye, Ma, Haonan, Fu, Fangteng, Wang, Bei
• Format: Article
• Language: English
• Subjects: Meta-analysis; Metabolic syndrome; Sleep
• ISSN: 0423-104X; 2299-8306
• DOI: 10.5603/EP.a2022.0058

INTRODUCTION: The association between sleep duration and metabolic syndrome (MetS) remains controversial, and few have considered the effects of sleep quality. We performed a meta-analysis to clarify the relationship of sleep duration and sleep quality with the risk of MetS. MATERIAL AND METHODS: We conducted a systematic and comprehensive literature search of electronic databases from inception to 17 February 2022. The effect sizes of covariates from each study were pooled using a random or fixed model, and a restricted cubic spline random-effects meta-analysis was performed to examine the dose-response relationship between sleep duration and MetS. RESULTS: A total of 62 studies were included in this meta-analysis. Compared to normal sleep duration, short sleep duration [odds ratio (OR) = 1.14, 95% confidence interval (CI): 1.10–1.19] and long sleep duration (OR = 1.15, 95% CI: 1.09–1.23) were associated with an increased risk of MetS. The restricted cubic spline analysis indicated that sleep durations of 8.5 h (OR = 0.95, 95% CI: 0.92–0.97) and 11 h (OR = 1.58, 95% CI: 1.31–1.91) were significantly associated with the risk of MetS. The pooled results showed that poor sleep quality (OR = 1.46, 95% CI: 1.03–2.06) and sleep complaints had significant positive associations with MetS. CONCLUSION: Our results demonstrated that short sleep duration increased the risk of developing MetS. Long sleep duration was also associated with MetS, especially for 11 h. 8.5 h can be considered the recommended sleep duration for MetS. Poor sleep quality and sleep complaints were also associated with MetS.