Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus

The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro dia...

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Bibliographic Details
Published in:	PloS one 2023-01, Vol.18 (1), p.e0280551
Main Authors:	Sy, Aminata, McCabe, Leanne, Hudson, Emma, Ansari, Azim M., Pedergnana, Vincent, Lin, Shang-Kuan, Santana, S., Fiorino, Marzia, Ala, Aftab, Stone, Ben, Smith, M., Nelson, Mark, Barclay, Stephen T., McPherson, Stuart, Ryder, Stephen D., Collier, Jane, Barnes, Eleanor, Walker, Ann Sarah, Pett, Sarah L., Cooke, Graham
Format:	Article
Language:	English
Subjects:	Analysis Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Biobanks Biology and Life Sciences Blood Consent Control Diagnostic systems Dosage and administration Gene sequencing Genetic screening Genetic testing Genotype Genotype & phenotype Genotypes Genotyping Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C virus Hepatitis C, Chronic - drug therapy HIV Human immunodeficiency virus Humans Identification and classification In vitro methods and tests Infections Interferon Interferons - therapeutic use Interleukins - genetics Laboratories Medical tests Medicine and health sciences Methods Nurses Point of care testing Polymorphism, Single Nucleotide Research and Analysis Methods Single nucleotide polymorphisms Single-nucleotide polymorphism Viruses
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