A general protocol for stereoselective construction of enaminyl sulfonyl fluorides

A simple, efficient, and mild reaction of 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) with amines was developed, affording a variety of highly functionalized enaminyl sulfonyl fluorides in good to excellent yields (56–96%). This transformation features a broad substrate scope, high atom economy, o...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2023-02, Vol.10 (4), p.951-956
Main Authors: Liu-Yang, Chen, Rakesh, K P, Hua-Li, Qin
Format: Article
Language:English
Subjects:
Amines
Atom economy
Fluorides
Organic chemistry
Stereoselectivity
Substrates
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Summary:A simple, efficient, and mild reaction of 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) with amines was developed, affording a variety of highly functionalized enaminyl sulfonyl fluorides in good to excellent yields (56–96%). This transformation features a broad substrate scope, high atom economy, operational simplicity and up to 100% stereoselectivity, which can provide great application value in medicinal chemistry, chemical biology, and drug discovery.
ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo01810a