Acrylic polymer nanoparticles: cytotoxicity, cell permeability, and biodistribution in mice after intravenous injection

Polymer nanoparticles are promising candidates for drug encapsulation and drug delivery systems. Particle surface functionalization allows for targeting specific sites, improving the drug distribution and hence potentializing the treatment of a wide range of diseases. In the present work, both the a...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2023-02, Vol.25 (2), p.35, Article 35
Main Authors: de Mattos, Gabriela Calidone, Campos, Izabella Maria Ferreira, Marques, Melissa F., Figueiredo, Claudia Pinto, Ferraz, Helen Conceição, Pinto, José Carlos
Format: Article
Language:English
Subjects:
Acids
Acrylic acid
Biodegradable materials
Biodistribution
Cell permeability
Characterization and Evaluation of Materials
Chemistry and Materials Science
Chronic illnesses
Cytotoxicity
Drug delivery
Drug delivery systems
Drugs
Fluorescence
Inorganic Chemistry
Intravenous administration
Intravenous infusion
Kidneys
Lasers
Materials Science
Methacrylic acid
Nanoparticles
Nanotechnology
Nervous system
Optical Devices
Optics
Permeability
Photonics
Physical Chemistry
Polymerization
Polymers
Polymethyl methacrylate
Research Paper
Toxicity
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Summary:Polymer nanoparticles are promising candidates for drug encapsulation and drug delivery systems. Particle surface functionalization allows for targeting specific sites, improving the drug distribution and hence potentializing the treatment of a wide range of diseases. In the present work, both the ability of polymeric nanoparticles to cross tissue membranes in Caco-2 cell cultures and the nanoparticle distribution among different tissues after intravenous infusion in mice are analyzed. Poly(methyl methacrylate- co -acrylic acid) and poly(methyl methacrylate- co -methacrylic acid) nanoparticles were prepared through miniemulsion polymerizations and functionalized with a fluorescence dye through covalent bonding. Cytotoxic effects were not observed in concentrations below of 1689 µg/mL for methacrylic particles and 2411 µg/mL for acrylic particles. Half-lives of nanoparticle circulation in animals were short, as particles were removed from the bloodstream after 30 min. Fluorescence analyses showed that polymer nanoparticles can reach different organs with very heterogeneous distributions, reaching maximum concentration in the kidneys. Graphical Abstract
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-023-05681-x