Preparation of a novel acidic functionalized diatomite and its catalytic application in the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives

Diatomite has been functionalized using 3-chloropropyl trimethoxysilane, hexamethylenetetramine, and chlorosulfonic acid to create Diatomie@Hexamethylenetetramine-SO 3 H (Diatomie@HMTA-SO 3 H) and characterized with EDS, TGA, XRD, SEM, and FT-IR methods. This novel heterogeneous catalyst was used fo...

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Bibliographic Details
Published in:Research on chemical intermediates 2023-03, Vol.49 (3), p.979-995
Main Authors: Riyahinia, Mehdi, Nazifi, Zahra Sadat, Aghaei, Hamidreza, Massah, Ahmad Reza
Format: Article
Language:English
Subjects:
Aldehydes
Ammonium acetate
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Diatomaceous earth
Hexamethylenetetramine
Inorganic Chemistry
Microorganisms
Physical Chemistry
Pseudomonas aeruginosa
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Summary:Diatomite has been functionalized using 3-chloropropyl trimethoxysilane, hexamethylenetetramine, and chlorosulfonic acid to create Diatomie@Hexamethylenetetramine-SO 3 H (Diatomie@HMTA-SO 3 H) and characterized with EDS, TGA, XRD, SEM, and FT-IR methods. This novel heterogeneous catalyst was used for the synthesis of 2,3-dihydroquinazolinone derivatives under solvent-free conditions using isatoic anhydride, different aldehydes, and ammonium acetate. The antibacterial activity of the synthesized compounds against two microorganisms, including a Gram-positive Staphylococcus aureus and a Gram-negative Pseudomonas Aeruginosa , was investigated by the Kirby-Bayer method. This method has several benefits, including high product purity and yield, short reaction times, simple work-up and purification procedures, and employing an environmentally friendly, affordable, recoverable, and reusable catalyst.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-022-04927-y