Single-dose Fosfomycin Tromethamine for Treatment of Urinary Tract Infection in Hong Kong Women: a Preliminary Prospective Study

Objective: To investigate the clinical efficacy and side-effect profile of a single 3-g dose of fosfomycin tromethamine in the treatment of Hong Kong women having uncomplicated urinary tract infections. Design: Prospective open-label uncontrolled study. Setting: Gynaecology outpatient clinic, Depart...

Full description

Saved in:
Bibliographic Details
Published in:Hong Kong journal of gynaecology, obstetrics, and midwifery = Xianggang fu chan zhu chan ke za zhi obstetrics, and midwifery = Xianggang fu chan zhu chan ke za zhi, 2012-01, Vol.12 (1), p.37
Main Authors: Chi-Wai TUNG, CHEON, Cecilia
Format: Article
Language:English
Subjects:
Antibiotics
E coli
Gynecology
Urinary tract diseases
Urinary tract infections
Urogenital system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To investigate the clinical efficacy and side-effect profile of a single 3-g dose of fosfomycin tromethamine in the treatment of Hong Kong women having uncomplicated urinary tract infections. Design: Prospective open-label uncontrolled study. Setting: Gynaecology outpatient clinic, Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, Hong Kong. Patients: Adult women with clinical symptoms of urinary tract infections, confirmed by microscopy and culture (colony-forming unit, >105 /ml) of mid-stream urine specimens. Results: Of 44 subjects studied, 98% returned for follow-up. Forty-eight hours after treatment with fosfomycin, the bacterial eradication rate was 86% (38/44), 91% (20/22), 100% (4/4), and 60% (3/5) for all bacteria, Escherichia coli (non-ESBL–producing strains), Escherichia coli (ESBL-producing strains), and Klebsiella, respectively. However, 19% of the subjects experienced diarrhoea. Conclusion: Our preliminary study suggests that a single dose of fosfomycin had a high bacterial eradication rate after 48 hours, compared to 1-week course of other antibiotics, but was associated with a high frequency of diarrhoea. Further studies using a larger sample size and longer follow-up are needed.
ISSN:1608-9367