The effect of auxiliary admixture equipment on the hygiene conditions and quality of Pharmacy Intravenous Admixture Services

• Published in: Applied nanoscience 2023-04, Vol.13 (4), p.2997-3006
• Main Authors: Li, Guochun, Xu, Hong, Zhao, Huaibi, Deng, Gulin, Huang, Xinwu
• Format: Article
• Language: English
• Subjects: Admixtures; Background noise; Chemistry and Materials Science; Control equipment; Dispensing; Endotoxins; Flow velocity; Hygiene; Illuminance; Inspection; Materials Science; Membrane Biology; Nanochemistry; Nanotechnology; Nanotechnology and Microengineering; Noise levels; Original Article; Parameters; Pharmacy; Quality control; Safety cabinets; Traditional Chinese medicine
• ISSN: 2190-5509; 2190-5517
• DOI: 10.1007/s13204-022-02369-x

The utilization of auxiliary admixture equipment can greatly improve the efficiency of dispensing drugs in Pharmacy Intravenous Admixture Services and ensure the quality of drug dispensing. However, the intravenous drug dispensing process has very high requirements for a clean environment, and it is unclear whether the introduction of auxiliary admixture equipment will affect the clean environment. Therefore, this paper explores the influence of auxiliary admixture equipment on intravenous drug dispensing environment and dispensing quality. We collected inspection data of biosafety cabinets, hand hygiene, and formulated medications using an auxiliary admixture equipment in Pharmacy Intravenous Admixture Services (PIVAS) of Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University from July to December 2020. We systematically assessed hygiene conditions, hand hygiene, and the quality of formulated medical solutions using an auxiliary admixture equipment. Under the operation of admixture equipment, the key parameters of biological safety cabinet are as follows: CFU of airborne bacteria/dish (0.5 h) = 0; number of floating particles (≥ 0.5 μm) = 0 or 71/m 3 ; number of floating particles ≥ 5 μm = 0/m 3 ; downstream flow rate = 0.29 m/s; the difference between the measured flow rate and the displayed average flow rate = 0.03 m/s; inflow air rate = 0.61 m/s; flow volume per meter in the working area = 0.12m3/s; working noise = 59.7 dB with a background noise = 54.9 dB; average illuminance value = 479Lx; the pass rate of hand hygiene and glove fingertip = 93.33% and 96.67%, respectively; and maximum number of insoluble particles in formulated solution = 22.4/ml (≥ 10 μm) and 0.7/ml (≥ 25 μm). Endotoxin was tested negative and the proportion of residual liquid was less than 5%. All the above parameters approved the quality control requirements. The results show that the use of auxiliary admixture equipment will not affect the clean environment while improving the efficiency of drug preparation, and can ensure the quality of prepared drug solution. It is worthy of popularization and application, and is of great significance to the development of intravenous drug preparation in the future.