Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis

• Published in: International urology and nephrology 2023-04, Vol.55 (4), p.1025-1032
• Main Authors: Kanbay, Mehmet, Yildiz, Abdullah Burak, Siriopol, Dimitrie, Vehbi, Sezan, Hasbal, Nuri Baris, Kesgin, Yavuz E., Celayir, Melisa, Selcukbiricik, Fatih, Covic, Adrian, Perazella, Mark A.
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - drug therapy; Autoimmunity; Biopsy; Comorbidity; Creatinine; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - adverse effects; Immunosuppressive agents; Immunotherapy; Kidney - pathology; Kidneys; Malignancy; Medicine; Medicine & Public Health; Mortality; Neoplasms - complications; Neoplasms - drug therapy; Nephritis; Nephrology; Nephrology - Original Paper; Patients; Prognosis; Retrospective Studies; Risk Factors; Statistical analysis; Urinary tract; Urology
• ISSN: 1573-2584; 0301-1623; 1573-2584
• DOI: 10.1007/s11255-022-03395-y

Background Immunotherapy with immune checkpoint inhibitors (ICPi) may cause acute kidney injury (AKI) and their use is increasing. Materials and methods This is a single-center retrospective cohort study of patients receiving ICPi drugs for solid organ malignancies. ICPi-related AKI, the need for renal replacement therapy during or following ICPi treatment, and the associated mortality was studied. Results Two hundred thirty five patients were included in the final analysis. Patients with ( N  = 40) and without ( n  = 195) AKI had similar age, sex, type of ICPi, baseline serum creatinine levels, comorbidities and mortality; while patients with AKI were more likely to be receiving a nephrotoxic agent or be treated for genitourinary malignancy. 18 patients had ICPi-related AKI; 7 of these patients underwent kidney biopsy, which showed acute interstitial nephritis while the remaining 11 were diagnosed on clinical parameters. 18 (45%) patients recovered kidney function after AKI. No differences were observed between patients with and without kidney function recovery, although patients without recovery had a numerical, but not statistically significant, higher mortality. Patients with biopsy-confirmed ICPi-induced AKI had an increased risk of mortality, as compared with the rest of the population—HR 1.83, 95% CI 1.22–2.74, p  = 0.003. Conclusion Use of nephrotoxic drugs and the location of malignancy appear to be common drivers of AKI in patients receiving ICPis for solid organ malignancy. Whether nephrotoxic agents or urinary tract obstruction may favor ICPi-related autoimmunity should be further studied.