Hyperuricemia: an unrecognized risk factor for kidney-related sequelae in children with hemolytic uremic syndrome

Background Chronic kidney-related sequelae after STEC-HUS occur in 20–40% of patients. Hyperuricemia (HU) may cause acute and chronic toxicity involving the kidneys. We retrospectively assessed if there was an association between the presence of HU during the acute illness and that of kidney-related...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2023-05, Vol.38 (5), p.1547-1557
Main Authors: Balestracci, Alejandro, Meni Battaglia, Luciana, Toledo, Ismael, Beaudoin, Laura, Martin, Sandra Mariel, Grisolía, Nicolás Ariel, Hogg, Ronald J.
Format: Article
Language:English
Subjects:
Case-Control Studies
Child
Children
Chronic toxicity
Complications
Complications and side effects
Creatinine
Diagnosis
Dialysis
Disease Progression
Escherichia coli Infections - complications
Hemodialysis
Hemolytic uremic syndrome
Hemolytic-Uremic Syndrome - complications
Hemolytic-Uremic Syndrome - epidemiology
Humans
Hyperuricemia
Hyperuricemia - complications
Hyperuricemia - epidemiology
Kidney
Kidneys
Medicine
Medicine & Public Health
Multivariate analysis
Nephrology
Original Article
Pediatrics
Renal Dialysis - adverse effects
Retrospective Studies
Risk Factors
Shiga-Toxigenic Escherichia coli
Uric Acid
Urology
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Summary:Background Chronic kidney-related sequelae after STEC-HUS occur in 20–40% of patients. Hyperuricemia (HU) may cause acute and chronic toxicity involving the kidneys. We retrospectively assessed if there was an association between the presence of HU during the acute illness and that of kidney-related sequelae in children with STEC-HUS. Methods Children with STEC-HUS who had clinical and laboratory data at 2 years of follow-up were included in this case–control study. Univariate and multivariate analyses were performed between patients with (cases) or without (controls) kidney-related sequelae to identify factors associated with outcomes, including different measures of serum uric acid (sUA) (baseline level, peak, and duration of HU). HU was defined as sUA > 8 mg/dL. Results Of 86 patients included, 77.9% had HU. Patients with sequelae ( n  = 41) had a higher prevalence of HU (41/41 vs. 26/45, p  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-022-05753-5