On-chip flow rate sensing via membrane deformation and bistability probed by microwave resonators

• Published in: Microfluidics and nanofluidics 2023-04, Vol.27 (4), p.28, Article 28
• Main Authors: Secme, Arda, Sedaghat Pisheh, Hadi, Tefek, Uzay, Uslu, H. Dilara, Kucukoglu, Berk, Alatas, Ceren, Kelleci, Mehmet, Hanay, M. Selim
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Biomedical Engineering and Bioengineering; Capacitance; Computer architecture; Deflection; Deformability; Deformation; Engineering; Engineering Fluid Dynamics; Flow measurement; Flow rates; Flow stability; Flow velocity; Fluid flow; Fluid-structure interaction; Formability; Lab-on-a-chip; Liquid flow; Membranes; Microfluidics; Nanotechnology and Microengineering; Pressure; Pulsation; Research Paper; Resonance; Resonators; Silicon nitride; Tracking; Transduction; Work platforms
• ISSN: 1613-4982; 1613-4990
• DOI: 10.1007/s10404-023-02640-9

Precise monitoring of fluid flow rates constitutes an integral problem in various lab-on-a-chip applications. While off-chip flow sensors are commonly used, new sensing mechanisms are being investigated to address the needs of increasingly complex lab-on-a-chip platforms which require local and non-intrusive flow rate sensing. In this regard, the deformability of microfluidic components has recently attracted attention as an on-chip sensing mechanism. To develop an on-chip flow rate sensor, here we utilized the mechanical deformations of a 220 nm thick Silicon Nitride membrane integrated with the microfluidic channel. Applied pressure and fluid flow induce different modes of deformations on the membrane, which are electronically probed by an integrated microwave resonator. The flow changes the capacitance, and in turn resonance frequency, of the microwave resonator. By tracking the resonance frequency, liquid flow was probed with the device. In addition to responding to applied pressure by deflection, the membrane also exhibits periodic pulsation motion under fluid flow at a constant rate. The two separate mechanisms, deflection and pulsation, constitute sensing mechanisms for pressure and flow rate. Using the same device architecture, we also detected pressure-induced deformations by a gas to draw further insight into the sensing mechanism of the membrane. Flow rate measurements based on the deformation and instability of thin membranes demonstrate the transduction potential of microwave resonators for fluid–structure interactions at micro- and nanoscales.