The Public Health Importance of Flaviviruses as an Etiological Environmental Factor in Nonsyndromic Cleft Lip and/or Palate: In silico Study

Objective This in silico study aims to investigate flaviviruses as an environmental factor in the etiology of nonsyndromic cleft lip and/or palate (CL/P). Design A scoring method with 7 topics—disease, transplacental passage, tropism, cellular damage, reported case, analysis of genome similarity, an...

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Bibliographic Details
Published in:The Cleft palate-craniofacial journal 2023-05, Vol.60 (5), p.544-550
Main Authors: Silva, Kaique Cesar de Paula, Messias, Thiago Silva, Soares, Simone
Format: Article
Language:English
Subjects:
Birth defects
Cleft Lip - etiology
Cleft Palate - etiology
Dengue
Dengue fever
Encephalitis
Etiology
Flavivirus - genetics
Humans
Public Health
West Nile Fever
West Nile virus
West Nile virus - genetics
Zika Virus
Zika Virus Infection
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Summary:Objective This in silico study aims to investigate flaviviruses as an environmental factor in the etiology of nonsyndromic cleft lip and/or palate (CL/P). Design A scoring method with 7 topics—disease, transplacental passage, tropism, cellular damage, reported case, analysis of genome similarity, and transcriptome between virus and host, was created based on literature and in silico experimentation. Viral genomes of NCBI virus were obtained and BLAST 2.12.0 was applied for the similarity analysis, adjusted to search for only human sequences related to CL/P with the statistical threshold defined for E-value ≤1. Results Flaviviruses with high potential to cause CL/P were: serotypes 2, 3, and 4 of the Dengue virus and lineage 2 of the West Nile virus, while the Yellow Fever virus, Japanese encephalitis virus, Tick-borne encephalitis virus, and Saint Louis encephalitis virus presented with medium potential to cause CL/P. As for the Zika virus, even strains associated with microcephaly showed only medium potential. Conclusions Dengue virus and West Nile virus presented with high potential to act as environmental factors in the etiology of CL/P.
ISSN:1055-6656
1545-1569
DOI:10.1177/10556656221074206