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Synthesis and properties of new derivatives of 4-amino-2,3-polymethylenequinolines with antioxidant function

New potential multitarget compounds based on 4-amino-2,3-polymethylenequinolines (analogs of tacrine) with different sizes of aliphatic rings conjugated with an ionol molecule as an antioxidant moiety were synthesized. The addition was accomplished through the ethyleneamine linker using an amide bon...

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Bibliographic Details
Published in:Russian chemical bulletin 2023-03, Vol.72 (3), p.802-806
Main Authors: Serkov, I. V., Proshin, A. N., Kovaleva, N. V., Boltneva, N. P., Rudakova, E. V., Makhaeva, G. F., Bachurin, S. O.
Format: Article
Language:English
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Summary:New potential multitarget compounds based on 4-amino-2,3-polymethylenequinolines (analogs of tacrine) with different sizes of aliphatic rings conjugated with an ionol molecule as an antioxidant moiety were synthesized. The addition was accomplished through the ethyleneamine linker using an amide bond. The study of the esterase profile of the synthesized compounds showed that they are highly efficient inhibitors of both acetylcholinesterase and butyrylcholinesterase with high selectivity for the latter and exhibit high antioxidant activity in the ABTS test (ABTS is the 2,2–-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)).
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-3844-8