Fast Expandable Chitosan‐Fibers Cryogel from Ambient Drying for Noncompressible Bleeding Control and In Situ Tissue Regeneration

Hemorrhage control, especially noncompressible wound hemostasis, is a tremendous challenge in military injuries and other traumas worldwide. Here, a cryogelation strategy and subsequent solvent exchange are developed for the hydrogen bond‐induced self‐assembly of chitosan fibers and the production o...

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Bibliographic Details
Published in:Advanced functional materials 2023-04, Vol.33 (16), p.n/a
Main Authors: Qi, Luhe, Mu, Lanxin, Guo, Xiaojia, Liu, Anxiong, Chen, Chaoji, Ye, Qifa, Zhong, Zibiao, Shi, Xiaowen
Format: Article
Language:English
Subjects:
Biocompatibility
Bleeding
Chitosan
cryogels
Drying
expandable hemostat
Hemorrhage
Hemostatics
Hydrogen bonds
Materials science
non‐compressible hemorrhage
Regeneration (physiology)
Response time (computers)
Self-assembly
Shape memory
shape recovery
Tissue engineering
Water absorption
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Summary:Hemorrhage control, especially noncompressible wound hemostasis, is a tremendous challenge in military injuries and other traumas worldwide. Here, a cryogelation strategy and subsequent solvent exchange are developed for the hydrogen bond‐induced self‐assembly of chitosan fibers and the production of fast expandable chitosan cryogel. Importantly, the ambient drying process facilitates the repeatable deformation performance of the shape‐memory cryogel with a response time of ≈1.7 s. Due to the capillary‐like structure of the cryogel and high hydrophilicity, rapid shape recovery is accompanied by 41 times water absorption ability. It is further demonstrated that chitosan cryogel is beneficial for in situ tissue regeneration by taking advantage of the biodegradability and biocompatibility of chitosan. Thus, chitosan cryogels prepared by this simple and benign method should have efficient hemostatic effect on noncompressible bleeding and severe fatal high‐pressure hemorrhage. A cryogelation strategy is adopted to prepare fast expandable chitosan‐fibers cryogel from ambient drying for noncompressible bleeding control and in situ tissue regeneration. The resulting compressible cryogel exhibits remarkable hemostatic effect on noncompressible bleeding due to rapid exudate absorption, fast expandability, and quick fibrin formation.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202212231