Computational model based approach to analyse potassium concentration and ion channel effects in ventricular ECG generation for normal and arrhythmic condition using Euler integration method - A simulation study

To analyse the Potassium (K+) ion concentration and channel effects in ventricular Electrocardiogram (ECG) generation for normal and arrhythmic conditions using the euler integration method. In this research human ventricular cells are taken based on the model of the human endocardial and epicardial...

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Bibliographic Details
Main Authors: Setti, Sucharitha, Subramanian, Nithyaselvakumari
Format: Conference Proceeding
Language:English
Subjects:
Electrocardiography
Failure analysis
Ion channels
Ion concentration
Membranes
Numerical methods
Potassium
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Summary:To analyse the Potassium (K+) ion concentration and channel effects in ventricular Electrocardiogram (ECG) generation for normal and arrhythmic conditions using the euler integration method. In this research human ventricular cells are taken based on the model of the human endocardial and epicardial cells by the Ten Tusscher, Nobel and Panflov (TNP model). Model is modified and interpredicted based on the experimental data of Han, describing the properties of K+ concentrations and channel dynamics in the ventricular ECG generation. Euler integration numerical method is used to analyse the TNP model for different channel and ion concentration failure conditions in the same group of 100 samples. Results: The normal intracellular K+concentration (K+) value is 138.3mM which having Action Potential (AP) mean value in the range of -70mV to 38mV, but for different abnormal such as (25%= 172.5mM, 50%=207mM, 100%=276.6mM) having AP of mean values like (25%=-19mv to 35mv, 50%= -18mv to 37mv, 100%=-16mv to 37.5mv). Similarly, its K+ membrane current mean values like K+ transient outward current (Ito), K+ inward current (IK1), K+ rapid current (Ikr) and K+ slow current (Iks) is having variations with respect to normal K+ membrane current. Out of all membrane currents Iks is having more effects in mean membrane current with respect to membrane currents (-0.149pA to -0.19pA with -0.04 to 0.05pA). Conclusion: This type of K+ membrane currents variations lead to delayed afterdepolarization (DAD) and in turns produce deep long ST segment waves, more deep negative T waves and absence of T waves in ventricular ECG.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0134693