Thermal and redox responsive polyamidoamine dendrimer–poly(N‐isopropylacrylamide) bridged by disulfide linkages for targeted and controlled drug delivery system

Multifactor‐responsive nanomaterials have been playing a vital role in drug delivery developments. Given the advantages of nanotechnology‐based systems, employing stimuli‐sensitive agents could offer a step forward to targeted drug delivery. Hence, we targeted to apply both thermal and redox‐sensiti...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied polymer science 2023-07, Vol.140 (27), p.n/a
Main Authors: Luu, Cuong Hung, Nguyen, Dinh Tien Dung, Chee, Ching Yern, Thi, Tram Chau Nguyen, Nguyen, Dong Yen Pham, Nguyen, Dai Hai, Nguyen, Cuu Khoa
Format: Article
Language:English
Subjects:
Biocompatibility
disulfide
Drug delivery systems
Materials science
Nanoengineering
Nanomaterials
Nanoparticles
NMR
Nuclear magnetic resonance
poly(N‐ispropylacrylamide)
Polyamidoamine
Polyisopropyl acrylamide
Polymers
Raman spectroscopy
redox‐responsive
Stimuli
Surface properties
thermal‐responsive
Zeta potential
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multifactor‐responsive nanomaterials have been playing a vital role in drug delivery developments. Given the advantages of nanotechnology‐based systems, employing stimuli‐sensitive agents could offer a step forward to targeted drug delivery. Hence, we targeted to apply both thermal and redox‐sensitive agents, which are poly(N‐isopropylacrylamide) (PNIPAM) and disulfide, onto a classic platform polyamidoamine (PAMAM) dendrimer. In particular, PAMAM G3.5 was first grafted by an outermost layer composed of cystamine moieties and partially grafted with PNIPAM segments. This novel nanomaterial was successfully verified by FTIR, 1H NMR, and Raman spectroscopy. Besides, morphological and surface characteristics were observed by DLS, TEM, and zeta potential. Our novel drug delivery system displayed a spherical shape with a hydrodynamic size of 43.61 ± 6.04 nm at 37°C and 68.99 ± 4.69 nm at 15°C, which proved its thermoresponsiveness. In parallel, the response of the nanoparticles toward redox concentration variation was testified that demonstrated a controlled drug release highly depending on physiological stimuli. We have also conducted in vitro DOX release and cytocompatibility of this drug delivery system, which can premise a smart strategy for nanoengineering in targeted drug delivery for cancer therapy. A novel drug delivery system based on PAPAM dendrimer platform that can response to temperature for enhancing drug encapsulation and control drug release for targeted therapy.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.54108