Direct access to β-arylketoesters by NHC/photoredox catalyzed alkoxycarbonylation–carbonylation of styrenes

We report herein a dicarbonylation of styrenes with aryl fluorides and potassium 2-ethoxy-2-oxoacetate by cooperative NHC and photoredox catalysis with good functional group tolerance and moderate to high yields. This gentle and efficient approach offers a valuable alternative to known strategies fo...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2023-06, Vol.10 (13), p.3288-3292
Main Authors: Liu, Yaomei, Wu, Zuming, Li, Wenjing, Zhang, Mengjiao, Zhang, Youhui, Deng, Shuqin, Fan, Shilu, Zhu, Yanwu, Yi-Si, Feng
Format: Article
Language:English
Subjects:
Carbonyls
Cascade chemical reactions
Catalysis
Functional groups
Organic chemistry
Photoredox catalysis
Potassium
Styrenes
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Summary:We report herein a dicarbonylation of styrenes with aryl fluorides and potassium 2-ethoxy-2-oxoacetate by cooperative NHC and photoredox catalysis with good functional group tolerance and moderate to high yields. This gentle and efficient approach offers a valuable alternative to known strategies for the synthesis of β-arylketoesters. Mechanistic studies have shown that this protocol proceeds via a radical-addition/coupling/elimination cascade reaction.
ISSN:2052-4110
2052-4110
DOI:10.1039/d3qo00515a