Novel Validated UV Spectroscopic Method for the Analysis of Ramipril and Olmesartan medoxomil in Drug Substance as Fixed Dosage Form

The current study focuses on the development and analytical validation of a unique, precise, and accurate UV-Visible Spectrophotometric method for estimating Ramipril and Olmesartan medoxomil simultaneously. The regression strength of Ramipril and Olmesartan medoxomil over its absorbances were obtai...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2023-03, Vol.16 (3), p.1442-1446
Main Authors: Kumar J, Navin, Sonia, K., Manikandan, K.
Format: Article
Language:English
Subjects:
Accuracy
Alcohol
Antihypertensives
Drug dosages
Humidity
Pharmaceuticals
Regulatory approval
Smooth muscle
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Summary:The current study focuses on the development and analytical validation of a unique, precise, and accurate UV-Visible Spectrophotometric method for estimating Ramipril and Olmesartan medoxomil simultaneously. The regression strength of Ramipril and Olmesartan medoxomil over its absorbances were obtained as y=0.0378x-0.05347 and y=0.0397x-0.0042 respectively with a correlation coefficient (r2) of 0.9917 for Ramipril and 0.9999 for Olmesartan medoxomil. The intra-day precision in addition inter-day precision for Ramipril and its % RSD were obtained as 1.46% and 1.40% respectively. The intra-day precision in addition inter-day precision for Olmesartan medoxomil and % RSD were obtained as 2.28% and 1.46% respectively.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2023.00237