Comparison of Microbiological Profile of Drained Intra-Abdominal Abscess in Patients with Crohn’s Disease and Colonic Diverticulitis

• Published in: Turkish journal of colorectal disease 2022-12, Vol.32 (4), p.252-257
• Main Authors: Al-Rubaie, Reem F., Alqaisi, Hayder, El-Hussuna, Alaa
• Format: Article
• Language: English
• Subjects: Abscesses; Bacteria; Crohn's disease; Diverticulitis; E coli; Pilot projects
• ISSN: 2536-4898; 2536-4901
• DOI: 10.4274/tjcd.galenos.2022.2022-9-3

Aim: To investigate the microbiological profile of intra-abdominal abscesses drained from patients with Crohn’s disease (CD) compared to patients with complicated diverticulitis coli (cDC). Method: This was a retrospective, cohort, pilot study. Inclusion criteria were adult patients who underwent percutaneous ultrasonographic/computed tomography (CT) guided drainage or aspiration of abscess. Cultures were performed for all patients and tested with Gram staining. Demographic data, pre-operative medications taken for CD, abscess size, antibiotic coverage after drainage, abscess recurrence, surgical resection, resection type and post-operative complications were investigated. Results: A total 44 patients with CD (n=18) and cDC (n=26) were investigated in this pilot study. Cultures showed mostly mixed Gram-positive and negative bacteria in both CD and cDC, but Gram-negative culture was more prevalent in cDC (p=0.029). The most common bacteria was Escherichia coli in both groups. Anaerobic bacteria were the second most common flora in patients with cDC, while Streptococcus, Enterococcus, Extended spectrum Beta Lactamase-producing organisms, Pseudomonas, Morganella and Proteus were the second most common in patients with CD. Conclusion: Mixed Gram-positive and negative bacteria with Escherichia coli were the most common bacteria in CD and cDC. Both groups also showed significant growth of Enterococci, Streptococci, and anaerobic bacteria in culture. Klebsiella pneumoniae was significantly more prevalent in patients with CD.