Prognostic Significance of Surgical Margin Status and Gleason Grade at the Positive Surgical Margin in Predicting Biochemical Recurrence After Radical Prostatectomy in a Turkish Patient Cohort

Objective: To investigate the prognostic role of positive surgical margin (PSM) features in addition to well-defined risk factors in predicting biochemical recurrence (BCR) after radical prostatectomy. Materials and Methods: This study used the prostate cancer database from the Urooncology Associati...

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Bibliographic Details
Published in:Üroonkoloji bülteni 2021-03, Vol.20 (1), p.26-33
Main Authors: Koparal, Murat Yavuz, Sözen, Tevfik Sinan, Aslan, Güven, Baltacı, Sümer, Süer, Evren, Müezzinoğlu, Talha, Akdoğan, Bülent, Türkeri, Levent
Format: Article
Language:English
Subjects:
Cancer surgery
Cancer therapies
Medical prognosis
Metastasis
Nomograms
Patients
Prostate cancer
Regression analysis
Statistical analysis
Survival analysis
Urological surgery
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Summary:Objective: To investigate the prognostic role of positive surgical margin (PSM) features in addition to well-defined risk factors in predicting biochemical recurrence (BCR) after radical prostatectomy. Materials and Methods: This study used the prostate cancer database from the Urooncology Association in Turkey. Clinical, surgical, pathological and follow-up data were recorded from the database. PSM features, including number, location, linear length and Gleason grade (GG) were also recorded. Kaplan-Meier survival analyses were performed to assess differences in BCR-free survival (BCR-FS). In order to identify prognostic factors affecting BCR-FS, univariate and multivariate Cox regression analyses were performed. Results: The study included 984 patients who met the eligibility criteria. The median follow-up time was 29 (minimum: 6, maximum: 210) months, and BCR was detected in 178 (18.1%) patients. BCR-FS was found to be significantly lower in patients with higher total prostate-specific antigen, higher International Society of Urological Pathology (ISUP) grade, extraprostatic extension (EPE), seminal vesicle invasion, lymphovascular invasion, lymph node involvement, PSM and GG at PSM (PSMGG) ≥4 (log-rank p
ISSN:2147-2122
2147-2270
DOI:10.4274/uob.galenos.2020.1564