Split-field versus extended-field step-and-shoot IMRT techniques in nasopharyngeal cancer: a report of acute and late toxicities

Aim:This study aimed to evaluate acute and late toxicities in nasopharyngeal cancer (NPC) patients who were treated between split-field (SF) and extended-field (EF) step-and-shoot intensity-modulated radiotherapy (IMRT) techniques.Materials and methods:Between January 2011 and October 2011, 21 NPC p...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radiotherapy in practice 2022-03, Vol.21 (1), p.74-80
Main Authors: Onchan, Wimrak, Nobnop, Wannapha, Traisathit, Patrinee, Chakrabandhu, Somvilai, Tharavichitkul, Ekkasit, Klunklin, Pitchayaponne, Jia-Mahasap, Bongkot, Chitapanarux, Imjai
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Cartilage
Chemotherapy
Clinical medicine
Lymphatic system
Metastasis
Neck
Original Article
Patients
Radiation therapy
Statistical analysis
Throat cancer
Toxicity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim:This study aimed to evaluate acute and late toxicities in nasopharyngeal cancer (NPC) patients who were treated between split-field (SF) and extended-field (EF) step-and-shoot intensity-modulated radiotherapy (IMRT) techniques.Materials and methods:Between January 2011 and October 2011, 21 NPC patients with stage I-IVB (7th edition American Joint Committee on Cancer Staging) were randomly assigned to undergo radiotherapy with SF or EF step-and-shoot IMRT technique.Results:At a median follow-up time of 60 months (range 3–77), we reported the comparable acute and late toxicities between the two techniques. One patient (9%) in SF-IMRT arm developed grade 3 acute skin toxicity.Findings:Both SF and EF step-and-shoot IMRT techniques for NPC patients did not produce any statistically significant differences in both acute and late toxicities. Although no difference in toxicity was observed, technical problems due to field matching management were the obstacles in utilisation of SF-IMRT in our routine practice.
ISSN:1460-3969
1467-1131
DOI:10.1017/S1460396920000874