Split ring resonator topology based microwave induced thermoacoustic imaging (SRR-MTAI)

Microwave-induced thermoacoustic imaging (MTAI) using low-energy and long-wavelength microwave photons has great potential in detecting deep-seated diseases due to its unique ability of visualizing intrinsic electric properties of tissue in high resolution. However, the low contrast in conductivity...

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Bibliographic Details
Published in:IEEE transactions on medical imaging 2023-08, Vol.42 (8), p.1-1
Main Authors: Liu, Qiang, Liang, Xiao, Li, Tingting, Chao, Weian, Qi, Weizhi, Jin, Tian, Gong, Yubin, Jiang, Huabei, Xi, Lei
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Diagnostic Imaging - methods
Electric fields
Electric properties
enhancement
Imaging
imaging contrast
Magnetic resonance imaging
Medical imaging
Microwave
Microwave Imaging
Microwaves
Neoplasms
Photons
Resonators
Rings (mathematics)
Sensitivity
Sensitivity enhancement
split ring resonator
Split ring resonators
Target detection
thermoacoustic imaging
Thermoacoustics
Tissues
Topology
Tumors
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Summary:Microwave-induced thermoacoustic imaging (MTAI) using low-energy and long-wavelength microwave photons has great potential in detecting deep-seated diseases due to its unique ability of visualizing intrinsic electric properties of tissue in high resolution. However, the low contrast in conductivity between a target (e.g., a tumor) and the surroundings sets a fundamental limit for achieving a high imaging sensitivity, which significantly hinders its biomedical applications. To overcome this limit, we develop a split ring resonator (SRR) topology based MTAI (SRR-MTAI) approach to achieve highly sensitive detection by precise manipulation and efficient delivery of microwave energy. The in vitro experiments show that SRR-MTAI demonstrates an ultrahigh sensitivity of distinguishing a 0.4% difference in saline concentrations and a 2.5-fold enhancement of detecting a tissue target which mimicks a tumor embedded at a depth of 2 cm. The in vivo animal experiments conducted indicate that the imaging sensitivity between a tumor and the surrounding tissue is increased by 3.3-fold using SRR-MTAI. The dramatic enhancement in imaging sensitivity suggests that SRR-MTAI has the potential to open new avenues for MTAI to tackle a variety of biomedical problems that were impossible previously.
ISSN:0278-0062
1558-254X
DOI:10.1109/TMI.2023.3250647