High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We profiled 189 proteins and whole transcriptome in multiple mouse tissue types with spatial CITE sequencing and then further a...

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Bibliographic Details
Published in:Nature biotechnology 2023-10, Vol.41 (10), p.1405-1409
Main Authors: Liu, Yang, DiStasio, Marcello, Su, Graham, Asashima, Hiromitsu, Enninful, Archibald, Qin, Xiaoyu, Deng, Yanxiang, Nam, Jungmin, Gao, Fu, Bordignon, Pino, Cassano, Marco, Tomayko, Mary, Xu, Mina, Halene, Stephanie, Craft, Joseph E., Hafler, David, Fan, Rong
Format: Article
Language:English
Subjects:
631/1647/2017
631/1647/2217/2018
631/61/475
Agriculture
Animals
Bar codes
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Brief Communication
Cells
Coronaviruses
COVID-19
Epitopes
Follicles
Gene Expression Profiling - methods
Human tissues
Humans
Immune response
Indexing
Life Sciences
Lymphocytes
Mapping
Medicine
Mice
Peptide mapping
Proteins
RNA, Messenger
Single-Cell Analysis
Skin diseases
Spleen
Transcriptome - genetics
Transcriptomes
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