Preparation, Structure, and Properties of Chitosan Microtubes

Procedures were developed for forming hollow cylindrical structures with the wall thickness in the micrometer range (microtubes) from chitosan solutions in citric, lactic, and glycolic acids. The procedures are based on the phase-transfer neutralization induced by the transport of ions (hereinafter,...

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Bibliographic Details
Published in:Russian journal of applied chemistry 2023, Vol.96 (1), p.59-72
Main Authors: Shipovskaya, A. B., Gegel, N. O., Babicheva, T. S., Golyadkina, A. A.
Format: Article
Language:English
Subjects:
Acid-base neutralization
Biocompatibility
Biodegradation
Biological properties
Blood vessels
Carotid arteries
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chitosan
Elastoplasticity
Glycolic acid
Industrial Chemistry/Chemical Engineering
Liquid-solid interfaces
Macromolecular Compounds and Polymeric Materials
Polyelectrolytes
Polymers
Sodium dodecylbenzenesulfonate
Sodium hydroxide
Triethanolamine
Wall thickness
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Summary:Procedures were developed for forming hollow cylindrical structures with the wall thickness in the micrometer range (microtubes) from chitosan solutions in citric, lactic, and glycolic acids. The procedures are based on the phase-transfer neutralization induced by the transport of ions (hereinafter, ion-induced reaction), occurring at the liquid–liquid or solid–liquid interface, namely, on the polymer-analogous conversion of the salt form of the polymer to the base form in a NaOH or triethanolamine medium or formation of a water-insoluble polyelectrolyte complex with sodium dodecylbenzenesulfonate. Comparative analysis of the dependences of the morphological, structural, elastoplastic, physicomechanical, and biological properties of the structures on the reaction conditions and kind of the organic acid and neutralizing agent was made. The microtubes prepared from a chitosan solution in glycolic acid by ion-induced neutralization at the solid–liquid interface in a NaOH or triethanolamine medium exhibit the optimum levels of strength and elasticity, comparable with those of a fragment of human carotid artery and xenopericardial patch. The hemo- and biocompatibility and controlled biodegradation of these materials make them promising as analogs of biodegradable blood vessel implants.
ISSN:1070-4272
1608-3296
DOI:10.1134/S1070427223010093