“On‐Water” Synthesis of Sterically Congested γ‐Ketophosphine Oxides Featuring a CF3‐ and P(O)‐Tetrasubstituted Carbon Center

The distinctive hydrophobic hydration effect in the aqueous solution contributes to the success of the phospha‐Michael reaction between β‐CF3‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access to biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-10, Vol.365 (20), p.3546-3552
Main Authors: Man‐Hang Feng, Wen‐Jun Ji, Bo‐Jie Huo, Xu, Hao, Ma, Mengtao, Zhi‐Liang Shen, Xue‐Qiang Chu
Format: Article
Language:English
Subjects:
Aqueous solutions
Carbon
Michael reaction
Oxides
Online Access:Get full text
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Summary:The distinctive hydrophobic hydration effect in the aqueous solution contributes to the success of the phospha‐Michael reaction between β‐CF3‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access to biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested CF3‐ and P(O)‐tetrasubstituted carbon center. More importantly, the resulting products could be further transformed into densely functionalized γ‐ketophosphine oxides containing a CF3‐ and P(O)‐tetrasubstituted carbon center.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300741