Access to 2‐Sulfonyl‐4‐arylphenols and 2,6‐Bis‐sulfonyl 5‐Aryl‐4‐arylidene‐2‐cyclohexenones via Metal Triflates‐Catalyzed Domino Cyclocondensation of 1,3‐Bis‐sulfonylacetones and 3‐Arylacroleins

Herein, metal triflates–catalyzed one‐pot domino cyclocondensation of 1,3‐bis‐sulfonylacetones and 3‐arylacroleins via (3+3) or (3+2+1) annulation has been proposed to construct diversified 2‐sulfonyl‐4‐arylphenols and 2,6‐bis‐sulfonyl 5‐aryl‐4‐arylidene‐2‐cyclohexenones. In this effective reaction,...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-11, Vol.365 (21), p.3680-3689
Main Authors: Chang, Meng‐Yang, Hsueh, Nai‐Chen
Format: Article
Language:English
Subjects:
Aromatic compounds
Chemical reactions
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Summary:Herein, metal triflates–catalyzed one‐pot domino cyclocondensation of 1,3‐bis‐sulfonylacetones and 3‐arylacroleins via (3+3) or (3+2+1) annulation has been proposed to construct diversified 2‐sulfonyl‐4‐arylphenols and 2,6‐bis‐sulfonyl 5‐aryl‐4‐arylidene‐2‐cyclohexenones. In this effective reaction, C−C and C=C bonds are formed via a cascade process and 3‐arylacrolein acts as a C3 and C1 synthon during the formation of a six‐membered ring system under mild conditions. A plausible mechanism has been proposed and discussed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300858