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Predictable Representation of Metabolic Synthesis Pathways of Vitamins and Short-Chain Fatty Acids in Obese Adults
Gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs) and vitamins, are involved in maintaining energy homeostasis, which is quite relevant in the context of obesity. The aim of this work was to screen the predictive representation of biosynthetic pathways for vitamins and SCFA...
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Published in: | Journal of evolutionary biochemistry and physiology 2023-09, Vol.59 (5), p.1510-1525 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs) and vitamins, are involved in maintaining energy homeostasis, which is quite relevant in the context of obesity. The aim of this work was to screen the predictive representation of biosynthetic pathways for vitamins and SCFAs based on the data of metagenomic gut microbiome sequencing in patients with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The study included two groups: a control group (
n
= 130) and obese patients (
n
= 133), with the latter group being further divided into subgroups with MHO (
n
= 38) and MUHO (
n
= 55). The predictive representation of metabolic pathways of vitamin and SCFA synthesis in stool samples was studied using the PICRUSt2 software. Obese patients demonstrated an increase in the representation of vitamin B1, B2, B5, B6, B7, B9, and K synthesis pathways, as well as a decrease in the main pathways of vitamin B12 synthesis. Meanwhile, the pattern of changes relied on the metabolic obesity phenotypes. MHO was accompanied by an imbalance in the pathways of B1 synthesis and an increase in the representation of vitamin K synthesis pathways, whereas MUHO led to an increase in the ability of the gut microbiota to produce vitamins B1, B2, B5, B6, B7, B9, and K, as well as to the suppression of B12 biosynthesis. In addition, patients with MUHO showed an increase in the representation of synthesis pathways for such SCFAs as acetate, propanoate and butanoate, which was not observed in MHO patients. Overall, the change in the representation of gut microbiota metabolic pathways in obese patients results from the “selection” of microorganisms under the impact of specific factors, which are more pronounced in MUHO. Thus, an imbalance in gut microbiota biosynthesis pathways of vitamins and SCFAs reflects a disruption of metabolic symbiosis within the macroorganism–microorganism (human–microbiome) superorganism. |
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ISSN: | 0022-0930 1608-3202 |
DOI: | 10.1134/S0022093023050058 |