G98 Attention deficits in paediatric sickle cell disease; links with nocturnal oxygen desaturation in adolescents, but not children

AimHomozygous sickle cell anaemia (SCA; HbSS) is associated with neurological compromise and attention difficulties. Previous work has shown tentative links between executive dysfunction and daytime oxygen desaturation in SCA. Previous work has not however examined the effects of nocturnal oxygen sa...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-05, Vol.102 (Suppl 1), p.A40-A41
Main Authors: Stotesbury, H, Kirkham, FJ, Balfour, P, Koelbel, M, Inusa, B, Chakraborty, S, Rees, DC, Downes, M, Kawadler, J
Format: Article
Language:English
Subjects:
Adolescent Development
Adolescents
Attention
Brain
Children
Cognitive ability
Economic Status
Hypoxia
Morbidity
Oxygen
Oxygen saturation
Pediatrics
Performance Tests
Reaction Time
Saturation
Sickle cell disease
Socioeconomics
Teenagers
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Summary:AimHomozygous sickle cell anaemia (SCA; HbSS) is associated with neurological compromise and attention difficulties. Previous work has shown tentative links between executive dysfunction and daytime oxygen desaturation in SCA. Previous work has not however examined the effects of nocturnal oxygen saturation on attention, nor has it considered whether any relationship is confounded by the effects of socio-economic status (SES) or age.MethodsThirteen children (8–12 years, 6 Female) and twentytwo adolescents (13–18 years, 11 Female) with SCA enrolled on the Prevention of Morbidity in Sickle Cell Disease Phase 2 randomised controlled trial of auto-adjusting continuous positive airways pressure underwent cognitive assessment at baseline, which included the Conners’ Continuous Performance Test (CPT). Overnight oximetry was conducted at home within two weeks of assessment. Multiple deprivation indices (MDI) were derived from postcodes.ResultsIn adolescents, after correcting for the effects of MDI, correlations were found between time spent with oxygen saturation
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2017-313087.97