Loading…

Light‐induced FeCl3‐catalyzed selective benzyl C−H chlorination with trifluoromethanesulfonyl chloride

Here we report a light‐induced FeCl3‐catalyzed approach for benzyl C−H chlorination with remarkable regioselectivity, which enables alkylbenzenes to be converted into versatile benzyl chlorides under mild conditions using trifluoromethanesulfonyl chloride (TfCl) as the chlorine source. DFT calculati...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-12, Vol.365 (23), p.4144-4149
Main Authors: Yang, Chen‐Xi, Liu, De‐Guang, Li, Li‐Juan, Zhang, Yu‐Xing, Xia, Xi‐Rui, Jiang, Hong, Cheng, Wan‐Min
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Here we report a light‐induced FeCl3‐catalyzed approach for benzyl C−H chlorination with remarkable regioselectivity, which enables alkylbenzenes to be converted into versatile benzyl chlorides under mild conditions using trifluoromethanesulfonyl chloride (TfCl) as the chlorine source. DFT calculations show that the dynamics preference of benzylic α−C−H chlorination is more pronounced by employing TfCl.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300672