P250 Acute pancreatitis in cystic fibrosis paediatric patients

• Published in: Archives of disease in childhood 2017-06, Vol.102 (Suppl 2), p.A131-A131
• Main Authors: Ritivoiu, Mirela, Comanici, Daniela Valentina, Codreanu, Ioana Florentina, Belivaca, Alina, Craiu, Mihai, Delia, Corina, Stan, Iustina
• Format: Article
• Language: English
• Subjects: Cystic fibrosis; Endocrine disorders; Gastroenteritis; Pancreatitis; Patients; Pediatrics; Serum levels; Vomiting
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2017-313273.338

Background and aimsCystic Fibrosis represents the most frequent monogenic autosomal recessive disease in Caucasians. Among multiple systemic determination, the pancreatic function is affected, with primordial exocrine dysfunction and second endocrine disorder. Acute pancreatitis is a rare complication in CF, rapid diagnosis allowing selection of patients for closer monitoring for recurrent events.Method5 year retrospective study, conducted in INSMC ‘Alessandrescu Rusescu’, Bucharest. All charts of our CF patients were revised and 48 patients aged>3 years were included. Acute clinical manifestation like : violent abdominal pain and vomiting associated with high amylase levels above 170ui/L, serum glucose, ALT, AST and BMI.Results3 patients were diagnosed with acute pancreatitis, with a frequency of 6,25%. None of the patients associated high glucose serum levels nor high AST or ALT. BMI was 17,3–18,07 kg/m2. One patient presented a recurrent event during the 5 year study. In 2 patients we found low compliance for PERT and in 1 patient Campylobacter Pylori acute gastroenteritis was associated.ConclusionsWe identified a higher frequency of acute pancreatitis among our patients ( 6,25% compared with 3,5% described in general population) possibly determined by low treatment compliance ( PERT and nutritional recommendation) and associated with digestive illnesses.