P1 Comparative evaluation of clinical efficacy of whey extensively hydrolyzed formula and casein-based extensively hydrolyzed formula in infants with cow’s milk protein allergy

Background and aimsCow’s milk protein allergy (CMPA) is the most common food allergy in children. Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-b...

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Published in:Archives of disease in childhood 2017-06, Vol.102 (Suppl 2), p.A35-A35
Main Authors: E, Borovik Tatiana, V, Bushueva Tatiana, A, Skvortsova Vera, G, Zvonkova Natalia, M, Guseva Irina
Format: Article
Language:English
Subjects:
Allergies
Allergy
Atopic dermatitis
Babies
Body weight gain
Bovine serum albumin
Casein
Comparative Analysis
Cow's milk
Dermatitis
Diet
Food allergies
Food intake
Immunoglobulin E
Immunological tolerance
Infants
Milk
Patients
Pediatrics
Proteins
Whey
Young Children
β-Lactoglobulin
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container_end_page A35
container_issue Suppl 2
container_start_page A35
container_title Archives of disease in childhood
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creator E, Borovik Tatiana
V, Bushueva Tatiana
A, Skvortsova Vera
G, Zvonkova Natalia
M, Guseva Irina
description Background and aimsCow’s milk protein allergy (CMPA) is the most common food allergy in children. Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-based extensively hydrolyzed formula (eCHF) in infants with cow’s milk protein allergy.Methods66 infants (4 to 12 months of age) with moderate and severe forms of CMPA were divided into 2 groups and received either eWHF (n=20) or eCHF (n=46) during 5 week period. SCORAD index, specific-IgE levels, weight gain were evaluated before and after study.ResultsAtopic dermatitis was present for 56.4% (37) infant, gastrointestinal (GI) symptoms took place in 8.8% (6), and combined skin and GI symptoms – in 34.8% (23) patients. Elevated specific-IgE level was found to bovine serum albumin (34.5%), casein (15.5%), β-lactoglobulin (19%) and to goat’s milk protein (43.1%). Diagnostic levels of antibodies to eWHF were detected in 12.1% (0,250–0,292 ng/ml), to eCHF in none of patients (0042 ng/ml). SCORAD index decreased in eWHF group from 44.0 to 16.3 in moderate forms and from 73.1 to 50.7 in severe forms. In eCHF group these scores decreased from 42.9 to 5.3 and from 83.1 to 9.7 respectively (p
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Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-based extensively hydrolyzed formula (eCHF) in infants with cow’s milk protein allergy.Methods66 infants (4 to 12 months of age) with moderate and severe forms of CMPA were divided into 2 groups and received either eWHF (n=20) or eCHF (n=46) during 5 week period. SCORAD index, specific-IgE levels, weight gain were evaluated before and after study.ResultsAtopic dermatitis was present for 56.4% (37) infant, gastrointestinal (GI) symptoms took place in 8.8% (6), and combined skin and GI symptoms – in 34.8% (23) patients. Elevated specific-IgE level was found to bovine serum albumin (34.5%), casein (15.5%), β-lactoglobulin (19%) and to goat’s milk protein (43.1%). Diagnostic levels of antibodies to eWHF were detected in 12.1% (0,250–0,292 ng/ml), to eCHF in none of patients (0042 ng/ml). SCORAD index decreased in eWHF group from 44.0 to 16.3 in moderate forms and from 73.1 to 50.7 in severe forms. In eCHF group these scores decreased from 42.9 to 5.3 and from 83.1 to 9.7 respectively (p&lt;0.05). Due to balanced composition of both formulas an average food intake in eWHF group for protein was 3.1±0.79 g/kg, and in eCHF – 2.9±0.8 g/kg, and for energy 118±0.2 kcal/kg and 114±0.2 kcal/kg respectively. Weight gain in spite of eliminating diet was corresponding to age references (564±68 g per month for 4–6 months infants and 430±124 g per month for 7–12 months infants).ConclusionsCasein-based extensively hydrolyzed formula is both clinically and immunologically more effective for treatment of moderate and severe forms of CMPA in paediatric patients than whey extensively hydrolyzed formula. Infants feeding eCHF have demonstrated weight gain and tolerance.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2017-313273.89</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Allergies ; Allergy ; Atopic dermatitis ; Babies ; Body weight gain ; Bovine serum albumin ; Casein ; Comparative Analysis ; Cow's milk ; Dermatitis ; Diet ; Food allergies ; Food intake ; Immunoglobulin E ; Immunological tolerance ; Infants ; Milk ; Patients ; Pediatrics ; Proteins ; Whey ; Young Children ; β-Lactoglobulin</subject><ispartof>Archives of disease in childhood, 2017-06, Vol.102 (Suppl 2), p.A35-A35</ispartof><rights>2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2017 (c) 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2017 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1906805141/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1906805141?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21378,21394,27924,27925,33611,33877,43733,43880,74221,74397</link.rule.ids></links><search><creatorcontrib>E, Borovik Tatiana</creatorcontrib><creatorcontrib>V, Bushueva Tatiana</creatorcontrib><creatorcontrib>A, Skvortsova Vera</creatorcontrib><creatorcontrib>G, Zvonkova Natalia</creatorcontrib><creatorcontrib>M, Guseva Irina</creatorcontrib><title>P1 Comparative evaluation of clinical efficacy of whey extensively hydrolyzed formula and casein-based extensively hydrolyzed formula in infants with cow’s milk protein allergy</title><title>Archives of disease in childhood</title><description>Background and aimsCow’s milk protein allergy (CMPA) is the most common food allergy in children. Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-based extensively hydrolyzed formula (eCHF) in infants with cow’s milk protein allergy.Methods66 infants (4 to 12 months of age) with moderate and severe forms of CMPA were divided into 2 groups and received either eWHF (n=20) or eCHF (n=46) during 5 week period. SCORAD index, specific-IgE levels, weight gain were evaluated before and after study.ResultsAtopic dermatitis was present for 56.4% (37) infant, gastrointestinal (GI) symptoms took place in 8.8% (6), and combined skin and GI symptoms – in 34.8% (23) patients. Elevated specific-IgE level was found to bovine serum albumin (34.5%), casein (15.5%), β-lactoglobulin (19%) and to goat’s milk protein (43.1%). Diagnostic levels of antibodies to eWHF were detected in 12.1% (0,250–0,292 ng/ml), to eCHF in none of patients (0042 ng/ml). SCORAD index decreased in eWHF group from 44.0 to 16.3 in moderate forms and from 73.1 to 50.7 in severe forms. In eCHF group these scores decreased from 42.9 to 5.3 and from 83.1 to 9.7 respectively (p&lt;0.05). Due to balanced composition of both formulas an average food intake in eWHF group for protein was 3.1±0.79 g/kg, and in eCHF – 2.9±0.8 g/kg, and for energy 118±0.2 kcal/kg and 114±0.2 kcal/kg respectively. Weight gain in spite of eliminating diet was corresponding to age references (564±68 g per month for 4–6 months infants and 430±124 g per month for 7–12 months infants).ConclusionsCasein-based extensively hydrolyzed formula is both clinically and immunologically more effective for treatment of moderate and severe forms of CMPA in paediatric patients than whey extensively hydrolyzed formula. Infants feeding eCHF have demonstrated weight gain and tolerance.</description><subject>Allergies</subject><subject>Allergy</subject><subject>Atopic dermatitis</subject><subject>Babies</subject><subject>Body weight gain</subject><subject>Bovine serum albumin</subject><subject>Casein</subject><subject>Comparative Analysis</subject><subject>Cow's milk</subject><subject>Dermatitis</subject><subject>Diet</subject><subject>Food allergies</subject><subject>Food intake</subject><subject>Immunoglobulin E</subject><subject>Immunological tolerance</subject><subject>Infants</subject><subject>Milk</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Whey</subject><subject>Young Children</subject><subject>β-Lactoglobulin</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNqFkU2O1DAQhS0EEs3AHSzNOoMrlTj2ErX4k0ZiFrC2HP8QN07S2OlpMqvZcAjuwYnmJONWs2AFUkmv9PRVvcUj5BLYFQDy1zqZwYZshhBtVTPoKgSsO7wS8gnZQMNFcZvmKdkwxrCSQojn5EXOO8agFgI35PcNPNz_3M7jXie9hFtH3a2Oh7LOE509NTFMwehInfdFzXoyj4NbqfuxuCmXi7jSYbVpjuuds9TPaTxETfVkqdHZhanqi9j_8WEq4_W0ZHoMy0DNfHy4_5XpGOI3uk_zUj5RHaNLX9eX5JnXMbtXf_SCfHn39vP2Q3X96f3H7ZvrqgeGXdUyJ4zvsPfGcm1Nw3iD3tXSet6itbUVHoXULYLRvgbZaA01out7y7lr8YJcnv-W_O8Hlxe1mw9pKpGqloCslR3v_kWBZFywFhooFD9T_bhT-xRGnVYFTJ16VH_3qE49qnOPSkh8BABTnCQ</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>E, Borovik Tatiana</creator><creator>V, Bushueva Tatiana</creator><creator>A, Skvortsova Vera</creator><creator>G, Zvonkova Natalia</creator><creator>M, Guseva Irina</creator><general>BMJ Publishing Group LTD</general><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201706</creationdate><title>P1 Comparative evaluation of clinical efficacy of whey extensively hydrolyzed formula and casein-based extensively hydrolyzed formula in infants with cow’s milk protein allergy</title><author>E, Borovik Tatiana ; V, Bushueva Tatiana ; A, Skvortsova Vera ; G, Zvonkova Natalia ; M, Guseva Irina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1037-50e8cf73bfcd6adc40643fe29df653dd2d8f389a531caf2194aa1233ebbd66e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Allergies</topic><topic>Allergy</topic><topic>Atopic dermatitis</topic><topic>Babies</topic><topic>Body weight gain</topic><topic>Bovine serum albumin</topic><topic>Casein</topic><topic>Comparative Analysis</topic><topic>Cow's milk</topic><topic>Dermatitis</topic><topic>Diet</topic><topic>Food allergies</topic><topic>Food intake</topic><topic>Immunoglobulin E</topic><topic>Immunological tolerance</topic><topic>Infants</topic><topic>Milk</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Proteins</topic><topic>Whey</topic><topic>Young Children</topic><topic>β-Lactoglobulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>E, Borovik Tatiana</creatorcontrib><creatorcontrib>V, Bushueva Tatiana</creatorcontrib><creatorcontrib>A, Skvortsova Vera</creatorcontrib><creatorcontrib>G, Zvonkova Natalia</creatorcontrib><creatorcontrib>M, Guseva Irina</creatorcontrib><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; 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Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-based extensively hydrolyzed formula (eCHF) in infants with cow’s milk protein allergy.Methods66 infants (4 to 12 months of age) with moderate and severe forms of CMPA were divided into 2 groups and received either eWHF (n=20) or eCHF (n=46) during 5 week period. SCORAD index, specific-IgE levels, weight gain were evaluated before and after study.ResultsAtopic dermatitis was present for 56.4% (37) infant, gastrointestinal (GI) symptoms took place in 8.8% (6), and combined skin and GI symptoms – in 34.8% (23) patients. Elevated specific-IgE level was found to bovine serum albumin (34.5%), casein (15.5%), β-lactoglobulin (19%) and to goat’s milk protein (43.1%). Diagnostic levels of antibodies to eWHF were detected in 12.1% (0,250–0,292 ng/ml), to eCHF in none of patients (0042 ng/ml). SCORAD index decreased in eWHF group from 44.0 to 16.3 in moderate forms and from 73.1 to 50.7 in severe forms. In eCHF group these scores decreased from 42.9 to 5.3 and from 83.1 to 9.7 respectively (p&lt;0.05). Due to balanced composition of both formulas an average food intake in eWHF group for protein was 3.1±0.79 g/kg, and in eCHF – 2.9±0.8 g/kg, and for energy 118±0.2 kcal/kg and 114±0.2 kcal/kg respectively. Weight gain in spite of eliminating diet was corresponding to age references (564±68 g per month for 4–6 months infants and 430±124 g per month for 7–12 months infants).ConclusionsCasein-based extensively hydrolyzed formula is both clinically and immunologically more effective for treatment of moderate and severe forms of CMPA in paediatric patients than whey extensively hydrolyzed formula. Infants feeding eCHF have demonstrated weight gain and tolerance.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/archdischild-2017-313273.89</doi></addata></record>
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subjects Allergies
Allergy
Atopic dermatitis
Babies
Body weight gain
Bovine serum albumin
Casein
Comparative Analysis
Cow's milk
Dermatitis
Diet
Food allergies
Food intake
Immunoglobulin E
Immunological tolerance
Infants
Milk
Patients
Pediatrics
Proteins
Whey
Young Children
β-Lactoglobulin
title P1 Comparative evaluation of clinical efficacy of whey extensively hydrolyzed formula and casein-based extensively hydrolyzed formula in infants with cow’s milk protein allergy
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