Pd()-Catalyzed tandem selective dehydrogenative [4+2] annulation of 2-methyl-1,3-cycloalkanediones with olefins

A practical and effective palladium-catalyzed selective dehydrogenative [4+2] annulation of 2-methyl-1,3-cycloalkanediones with olefins was reported. The active 2-methylene-1,3-cycloalkanedione was in situ generated via Pd-catalyzed enolate oxidation processes, and it subsequently reacted with a wid...

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Published in:Chemical communications (Cambridge, England) England), 2024-01, Vol.6 (5), p.594-597
Main Authors: Zhang, Xu, Wang, Di, Chang, Mengfan, Xu, Xuefeng, Li, Wenguang, Wang, Wanya
Format: Article
Language:English
Subjects:
Alkenes
Chemical reactions
Dehydrogenation
Organic chemistry
Oxidation
Palladium
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Summary:A practical and effective palladium-catalyzed selective dehydrogenative [4+2] annulation of 2-methyl-1,3-cycloalkanediones with olefins was reported. The active 2-methylene-1,3-cycloalkanedione was in situ generated via Pd-catalyzed enolate oxidation processes, and it subsequently reacted with a wide variety of olefins to afford various polysubstituted dihydropyran derivatives in good to excellent yields. A practical and effective palladium-catalyzed dehydrogenative [4+2] annulation of 2-methyl-1,3-cycloalkanediones with a wide variety of olefins to afford various polysubstituted dihydropyran derivatives in good to excellent yields was reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05191a