In vitro release and cytotoxicity activity of 5-fluorouracil entrapped polycaprolactone nanoparticles

In this study, 5-fluorouracil (5-FU) entrapped polycaprolactone nanoparticles (5-FU- PCNPs) have been prepared using double emulsion method. The different factors were examined for assembly to arrive at the best effective formulation of 5-FU-PCNPs formulation for 5-FU–PCNPs, as polymer concentration...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2022-08, Vol.79 (8), p.6645-6671
Main Authors: Samy, Moshera, Abdallah, Heba M., Awad, Hanem M., Ayoub, Magdy M. H.
Format: Article
Language:English
Subjects:
Acids
Anticancer properties
Bioavailability
Cancer therapies
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Cytotoxicity
Double emulsions
Drug delivery systems
Efficiency
Nanoparticles
Organic Chemistry
Original Paper
Physical Chemistry
Polycaprolactone
Polymer Sciences
Polymers
Polyvinyl alcohol
Soft and Granular Matter
Solvents
Sustained release
Tumors
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Summary:In this study, 5-fluorouracil (5-FU) entrapped polycaprolactone nanoparticles (5-FU- PCNPs) have been prepared using double emulsion method. The different factors were examined for assembly to arrive at the best effective formulation of 5-FU-PCNPs formulation for 5-FU–PCNPs, as polymer concentration, stabilizer concentration. The encapsulation efficiency of PCNPs was in the range of 18.8–45.4%. The prepared nanoparticles showed the spherical shape having an average size of 183–675.5 nm, whereas TEM exhibited the prepared nanoparticles have a spherical shape. FTIR, XRPD, confirmed successful insertion of drug in prepared PCNPs. In vitro release of 5-FU from selected formulations showed sustained release from the nanoparticles where slower release was observed when lower PVA concentration was used. Anticancer activity was examined against cell culture for HCT-116 (human colorectal carcinoma), MCF-7(human breast adenocarcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human lung carcinoma) for six formulations 5-FU–PCNPs nanoparticles. The in vitro cytotoxic activity of the prepared formulations was tested showing that these formulations appeared as promising active anticancer formulations.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-021-03804-9