A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo

Levels of reactive oxygen species (ROS) in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology. However, due to the lack of adequate tools, it is difficult to stu...

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Bibliographic Details
Published in:Science China. Chemistry 2020-08, Vol.63 (8), p.1153-1158
Main Authors: Wei, Peng, Liu, Lingyan, Yuan, Wei, Yang, Jiajia, Li, Ruohan, Yi, Tao
Format: Article
Language:English
Subjects:
Cancer
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Design
Fluorescent indicators
Physiology
Tumors
Visualization
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Summary:Levels of reactive oxygen species (ROS) in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology. However, due to the lack of adequate tools, it is difficult to study the relationship between ROS, especially certain types of ROS ( e.g. , HOCl), and cancer. We report herein an HOCl-specific fluorescent probe, FDOCl-20 , containing a thiocarbamide group as a receptor, for the visualization of HOCl in solid tumors in vivo . This probe displays high selectivity and sensitivity to HOCl, and is appropriate for use in acidic conditions, including the tumor microenvironment. Using FDOCl-20 as a tool, we can visualize HOCl in solid tumors in vivo . Importantly, the fluorescent intensity of FDOCl-20 is proportional to tumor volume. Thus, FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-020-9737-y