Nutritional programming: Theoretical concepts and experimental evidence

It is known that malnutrition during prenatal development increases the risk of chronic conditions in adulthood. This phenomenon is referred to as the nutritional programming of age-related disorders. It is assumed that the qualitative or quantitative deficiency of certain nutrients during early dev...

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Bibliographic Details
Published in:Advances in gerontology 2014, Vol.4 (1), p.3-11
Main Authors: Zabuga, O. G., Akhaladze, N. G., Vaiserman, A. M.
Format: Article
Language:English
Subjects:
Aging
Animals
Birth weight
Chronic illnesses
Diet
Dietary restrictions
Epigenetics
Experiments
Females
Gender differences
Geriatrics/Gerontology
Gerontology
Glucose
Homeostasis
Hypertension
Kidneys
Malnutrition
Medicine
Medicine & Public Health
Mothers
Nutrition
Obesity
Pregnancy
Prenatal development
Proteins
Rodents
Sheep
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Summary:It is known that malnutrition during prenatal development increases the risk of chronic conditions in adulthood. This phenomenon is referred to as the nutritional programming of age-related disorders. It is assumed that the qualitative or quantitative deficiency of certain nutrients during early development elicits an adaptive response, which improves survival in prenatal and early postnatal life. However, a side effect of the adaptive changes may be the development of various disorders at later stages of life. Recent studies indicate that one of the major mechanisms involved in these changes is the epigenetic regulation of gene activity. In this review, we consider experimental data proving that processes arising from a quantitatively or qualitatively restricted diet at early developmental stages play an important role in further life and notably influence the risk of various age-related disorders and life span.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057014010159