Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Comprehensive Summary Psoriasis is a chronic immune‐mediated inflammatory skin disease and the TNF‐α is an important therapeutic target of this disease. In our continuous study of bioactive natural products from fungi, the first ergosterol‐polyether adducts, polyaspers A (1) and B (2), along with tw...

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Bibliographic Details
Published in:Chinese journal of chemistry 2024-04, Vol.42 (7), p.743-751
Main Authors: Hu, Hong, Li, Lanqin, Shi, Zhengyi, Lan, Xueqi, Zhang, Yeting, Huang, Xinye, Hao, Xincai, Zhou, Qun, Sun, Weiguang, Qi, Changxing, Zhang, Yonghui
Format: Article
Language:English
Subjects:
Actinomycin
Adducts
Animal models
Aspergillus
Aspergillus sp. TJ507
Biological activity
Cell death
Cell viability
Ergosterol
Ergosterol‐polyether adducts
Imiquimod
Inflammatory response
Inflammatory skin disease
Inhibitors
Lead compounds
Natural products
Psoriasis
Signs and symptoms
Skin diseases
Therapeutic targets
TNF‐α
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