Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction

Spectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 s...

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Bibliographic Details
Published in:The Journal of physiology 2024-03, Vol.602 (6), p.1127-1145
Main Authors: Sert, Ozlem, Ding, Xiaoyun, Zhang, Chuansheng, Mi, Ruifa, Hoke, Ahmet, Rasband, Matthew N.
Format: Article
Language:English
Subjects:
Actin
Actin Cytoskeleton - metabolism
Animals
axon injury
Axons
Cell size
Cytoskeleton
Erythrocytes
Humans
Mice
Muscle, Skeletal - metabolism
Muscular Diseases
Musculoskeletal system
Myopathy
neuromuscular junction
Neuromuscular Junction - metabolism
Neuromuscular junctions
Neurons
Neuropathy
Protein transport
regeneration
repair
Skeletal muscle
Sodium channels
Sodium channels (voltage-gated)
Sodium Channels - metabolism
Spectrin
Spectrin - analysis
Spectrin - genetics
Spectrin - metabolism
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