C-H activation-initiated spiroannulation reactions and their applications in the synthesis of spirocyclic compounds

Spirocyclic skeletons are prevalent in natural products, pharmaceuticals and organic functional materials. Meanwhile, transition-metal-catalyzed C-H activation reactions have demonstrated unparalleled advantages such as high efficiency, excellent atom-economy, good chemoselectivity and regioselectiv...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-03, Vol.22 (12), p.2324-2338
Main Authors: Zhou, Qianting, Li, Bin, Zhang, Xinying, Fan, Xuesen
Format: Article
Language:English
Subjects:
Alkenes
Alkynes
Atom economy
Chemical reactions
Chemical synthesis
Functional materials
Natural products
Organic chemistry
Quinones
Regioselectivity
Transition metals
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Summary:Spirocyclic skeletons are prevalent in natural products, pharmaceuticals and organic functional materials. Meanwhile, transition-metal-catalyzed C-H activation reactions have demonstrated unparalleled advantages such as high efficiency, excellent atom-economy, good chemoselectivity and regioselectivity for the formation of target organic molecules. In recent years, C-H activation reactions have been creatively utilized in the synthesis of spirocyclic compounds. This review summarizes the most recent progress made in C-H activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds by using alkynes, diazo compounds, maleimides, alkenes, quinones and cyclopropenones as the coupling partners. This review summarizes the most recent progress made in C-H bond activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob02056h