Revolutionizing personalized medicine with generative AI: a systematic review

Background Precision medicine, targeting treatments to individual genetic and clinical profiles, faces challenges in data collection, costs, and privacy. Generative AI offers a promising solution by creating realistic, privacy-preserving patient data, potentially revolutionizing patient-centric heal...

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Bibliographic Details
Published in:The Artificial intelligence review 2024-04, Vol.57 (5), p.128, Article 128
Main Authors: Ghebrehiwet, Isaias, Zaki, Nazar, Damseh, Rafat, Mohamad, Mohd Saberi
Format: Article
Language:English
Subjects:
Artificial Intelligence
Bioinformatics
Computer Science
Customization
Data collection
Generative adversarial networks
Generative artificial intelligence
Interdisciplinary studies
Large language models
Medical imaging
Model accuracy
Precision medicine
Privacy
Synthetic data
Systematic review
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Summary:Background Precision medicine, targeting treatments to individual genetic and clinical profiles, faces challenges in data collection, costs, and privacy. Generative AI offers a promising solution by creating realistic, privacy-preserving patient data, potentially revolutionizing patient-centric healthcare. Objective This review examines the role of deep generative models (DGMs) in clinical informatics, medical imaging, bioinformatics, and early diagnostics, showcasing their impact on precision medicine. Methods Adhering to PRISMA guidelines, the review analyzes studies from databases such as Scopus and PubMed, focusing on AI's impact in precision medicine and DGMs' applications in synthetic data generation. Results DGMs, particularly Generative Adversarial Networks (GANs), have improved synthetic data generation, enhancing accuracy and privacy. However, limitations exist, especially in the accuracy of foundation models like Large Language Models (LLMs) in digital diagnostics. Conclusion Overcoming data scarcity and ensuring realistic, privacy-safe synthetic data generation are crucial for advancing personalized medicine. Further development of LLMs is essential for improving diagnostic precision. The application of generative AI in personalized medicine is emerging, highlighting the need for more interdisciplinary research to advance this field.
ISSN:1573-7462
0269-2821
1573-7462
DOI:10.1007/s10462-024-10768-5