Brown tumour

This is osteitis fibrosa, a destructive skeletal mass that is also known as a brown tumour because of its histopathological appearance related to haemosiderin deposits (fig 1). This woman in her 30s presented with a six month history of painless, progressive mandibular swelling. She was having regul...

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Bibliographic Details
Published in:BMJ (Online) 2023-06, Vol.381, p.e071564
Main Authors: Henderson, Scott R, Hamour, Sally
Format: Article
Language:English
Subjects:
Bone diseases
Case reports
Endocrine disorders
Maxillofacial surgery
Minerva
Mouth
Reconstructive surgery
Tumors
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Summary:This is osteitis fibrosa, a destructive skeletal mass that is also known as a brown tumour because of its histopathological appearance related to haemosiderin deposits (fig 1). This woman in her 30s presented with a six month history of painless, progressive mandibular swelling. She was having regular haemodialysis for end stage renal failure. Blood tests showed low calcium, raised alkaline phosphatase, and raised parathyroid hormone levels indicative of secondary hyperparathyroidism despite medical treatment. Persistent hyperparathyroidism may occur as a severe complication of chronic kidney disease and causes complications associated with high bone turnover. This woman underwent parathyroidectomy, the definitive treatment, as well as reconstructive oral surgery, with a good outcome. Early management of hyperparathyroidism associated with chronic kidney disease may prevent skeletal abnormalities.
ISSN:1756-1833
1756-1833
DOI:10.1136/bmj-2022-071564.r1