Preparation and properties of poly(ethylene glycol)-b-poly(3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

To overcome the pain and risk of hypoglycemia in insulin administration, glucose-responsive microneedles have been developed by researchers, which could release insulin according to the blood glucose level. We designed a kind of particles by a reversible addition-fragmentation chain transfer (RAFT)...

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Bibliographic Details
Published in:Journal of Zhejiang University. A. Science 2024-05, Vol.25 (5), p.395-410
Main Authors: Hong, Yichuan, Yu, Haojie, Wang, Li, Chen, Xiang, Shen, Di, Wang, Yu, Ren, Shuning, Huang, Yudi, Yang, Jian
Format: Article
Language:English
Subjects:
Biosafety
Block copolymers
Blood
Blood glucose
Blood levels
Chain transfer
Civil Engineering
Classical and Continuum Physics
Engineering
Glucose
Hyaluronic acid
Hydrophobicity
Hypoglycemia
Industrial Chemistry/Chemical Engineering
Insulin
Mechanical Engineering
Needles
Polyethylene glycol
Research Article
Self-assembly
Substrates
Synthesis
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Summary:To overcome the pain and risk of hypoglycemia in insulin administration, glucose-responsive microneedles have been developed by researchers, which could release insulin according to the blood glucose level. We designed a kind of particles by a reversible addition-fragmentation chain transfer (RAFT) method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin. poly(ethylene glycol) (PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid (DDMAT) was synthesized as a macromolecular RAFT agent, which was then reacted with 3-acrylamidophenylboronic acid (AAPBA) to synthesize the block copolymer PEG- b -PAAPBA. Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions. Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate. The insulin release behavior of the particles in glucose solutions of 0, 100, and 400 mg/dL showed significant glucose responsiveness and good biosafety. The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.
ISSN:1673-565X
1862-1775
DOI:10.1631/jzus.A2300386