Revisiting the shikimate pathway and highlighting their enzyme inhibitors

Absent in animals and with only seven enzymatic reactions toward the synthesis of chorismate and aromatic amino acids, the shikimate pathway is a crucial target for developing antimicrobial agents and herbicides. Although this pathway has been extensively studied in microorganisms related to human h...

Full description

Saved in:
Bibliographic Details
Published in:Phytochemistry reviews 2024-04, Vol.23 (2), p.421-457
Main Authors: Almeida, Aline Marengoni, Marchiosi, Rogério, Abrahão, Josielle, Constantin, Rodrigo Polimeni, dos Santos, Wanderley Dantas, Ferrarese-Filho, Osvaldo
Format: Article
Language:English
Subjects:
Amino acids
Antimicrobial agents
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Chemical synthesis
Chemistry/Food Science
Enzyme inhibitors
Enzymes
Herbicides
Life Sciences
Metabolic pathways
Microorganisms
Organic Chemistry
Plant Genetics and Genomics
Plant Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Absent in animals and with only seven enzymatic reactions toward the synthesis of chorismate and aromatic amino acids, the shikimate pathway is a crucial target for developing antimicrobial agents and herbicides. Although this pathway has been extensively studied in microorganisms related to human health, it reveals complexities in plants, as it takes part in primary and secondary metabolism. Obtaining enzyme inhibitors is essential to circumvent the occurrence of weeds resistant to commercially available herbicides and to help control human diseases, which has challenged researchers to search for new molecules and investigate their modes of action. By applying bioinformatics tools, thousands of enzyme inhibitors of this metabolic pathway can be prospected at a low cost and in a short time. Here, we revisit how the enzymes of the shikimate pathway have been characterized and update the status of their inhibitors in microorganisms and plants. This overview can be constructive in searching for enzyme inhibitors in the academic, human health, and agro-industrial fields.
ISSN:1568-7767
1572-980X
DOI:10.1007/s11101-023-09889-6