Lomics: Generation of Pathways and Gene Sets using Large Language Models for Transcriptomic Analysis

Interrogation of biological pathways is an integral part of omics data analysis. Large language models (LLMs) enable the generation of custom pathways and gene sets tailored to specific scientific questions. These targeted sets are significantly smaller than traditional pathway enrichment analysis l...

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Bibliographic Details
Published in:arXiv.org 2024-07
Main Authors: Chun-Ka Wong, Choo, Ali, Cheng, Eugene C C, Wing-Chun, San, Kelvin Chak-Kong Cheng, Yee-Man Lau, Lin, Minqing, Li, Fei, Wei-Hao, Liang, Song-Yan, Liao, Kwong-Man Ng, Ivan Fan-Ngai Hung, Hung-Fat Tse, Wong, Jason Wing-Hon
Format: Article
Language:English
Subjects:
Bioinformatics
Data analysis
Hypothesis testing
Interrogation
Large language models
Python
Questions
Online Access:Get full text
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Summary:Interrogation of biological pathways is an integral part of omics data analysis. Large language models (LLMs) enable the generation of custom pathways and gene sets tailored to specific scientific questions. These targeted sets are significantly smaller than traditional pathway enrichment analysis libraries, reducing multiple hypothesis testing and potentially enhancing statistical power. Lomics (Large Language Models for Omics Studies) v1.0 is a python-based bioinformatics toolkit that streamlines the generation of pathways and gene sets for transcriptomic analysis. It operates in three steps: 1) deriving relevant pathways based on the researcher's scientific question, 2) generating valid gene sets for each pathway, and 3) outputting the results as .GMX files. Lomics also provides explanations for pathway selections. Consistency and accuracy are ensured through iterative processes, JSON format validation, and HUGO Gene Nomenclature Committee (HGNC) gene symbol verification. Lomics serves as a foundation for integrating LLMs into omics research, potentially improving the specificity and efficiency of pathway analysis.
ISSN:2331-8422