BCS Class II and IV Drug´s Solubilisation using Cycodextrin-PVPPEG6000 Complexes through a Factorial Study Design

Objective: Class II and IV drug on the Biopharmaceutical Classification System are those with the commonest solubility issues. The objective of this work is to study the effect of the use of cyclodextrin combined with each PVP, and PEG 6000 individually, then combined, and the enhancement of solubil...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2024-06, Vol.17 (6), p.2639-2643
Main Authors: El Baraka, Soumaya, Yanisse, Siham, Chefchaouni, Ali Cherif, Fahry, Aicha, Laatiris, Abdelkader, Cherkaoui, Naoual, El Alaoui, Yasser, Rahali, Younes
Format: Article
Language:English
Subjects:
Dissolution
Drugs
Ethanol
Factorial experiments
Permeability
Pharmaceutical industry
Surfactants
Variance analysis
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Summary:Objective: Class II and IV drug on the Biopharmaceutical Classification System are those with the commonest solubility issues. The objective of this work is to study the effect of the use of cyclodextrin combined with each PVP, and PEG 6000 individually, then combined, and the enhancement of solubility and dissolution rate on three BCS class II celecoxib and Valsarían, and Class IV Furosemide. Methods: A serie of 23factorial experiments were conducted. Drug's solubilities were assessed in eight selected fluids containing Beta Cyclodextrin, Polyvinylpyrrolidone and Poly Ethylene Glycol 6000 individually and in binary and ternary combinations. Solid inclusion complexes of each drug beta Cyclodextrin, Polyvinylpyrrolidone and Poly Ethylene Glycol 6000 were prepared by kneading method, to evaluation the impact of each excipient on dissolution rates per 23factorial design. Results: Solubility levels of the three studied drugs was highly enhanced by the studied excipients. The highest solubility improvement was recorded for the combination of BCD with PEG 6000 (4,95ratio) IN THE CASE OF Celecoxib, and forß-CD in combination with PEG 6000 and PVP (25,52 ratio) in the case of FSD, then in the combination of BCD with PEG 6000 (21, 41ratio) in the case of Valsarían. The highest enhancement of celecoxib dissolution raies was recorded for CCX-BCD (1:2) - PEG 6000 (2%) combinaiion (10,03 ratio), for FSD- BCD (1:2)-PEG 6000 (2%)-PVP (2%) combinaiion (22,61 ratio) in the case of furosemide and for VST-PVP (2%) combination (3,54ratio) in the case of Valsarían. Conclusion: PEG 6000 is a suitable solubilizer alone and in combination with BCD and PVP lo enhance the solubility and dissolution rale of the selected three BCS Class II and IV drugs.
ISSN:0974-3618
0974-306X
DOI:10.52711/0974-360X.2024.00413