Biodegradable microfibrous, electrospunned hydroxyapatite nanoparticles/poly(glycerol sebacate)-co-poly(ε-caprolactone) nanocomposite scaffolds for tissue engineering applications

• Published in: Polymer bulletin (Berlin, Germany) Germany), 2024-08, Vol.81 (13), p.11499-11515
• Main Authors: Pourhoseyini, Tahere, Naeimi, Farid, Mehrazin, Mehdi, Madadi, Mozhdeh, Khonakdar, Hossein Ali
• Format: Article
• Language: English
• Subjects: Acids; Biocompatibility; Biomedical materials; Biopolymers; Bones; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Composite materials; Copolymers; Cytokines; Elastomers; Extracellular matrix; Fourier transforms; Glycerol; Hydroxyapatite; Mechanical properties; Morphology; Nanocomposites; Nanoparticles; Organic Chemistry; Original Paper; Physical Chemistry; Polycaprolactone; Polyester resins; Polyglycerols; Polymer Sciences; Polymerization; Polymers; Pore size; Salt; Scaffolds; Scanning electron microscopy; Sodium; Soft and Granular Matter; Soft tissues; Spectrum analysis; Surfactants; Tissue engineering; Viscosity
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-024-05235-8

Soft tissue engineering has focused on green, solvent-free biopolymers with rubber-like characteristics. One of the well-known elastomeric polyesters is polyglycerol sebacate (PGS). The present investigation involves the synthesis of a novel biopolymer composed of PGS- co -poly(ε-caprolactone) (PCL) copolymer, alongside hydroxyapatite (HA) using bovine bone. These synthesized materials were utilized to build scaffolds using 18–22 kV electrospinning. By in situ polymerization, PGS- co -PCL/HA nanocomposites with 5% and 10% hydroxyapatite nanoparticles were developed. Various analysis such as FTIR, TGA, SEM, and DSC were utilized to examine the prepared samples. Introducing 10% HA to the PGS- co -PCL copolymer blends boosted nanocomposite mechanical strength by 300%. Meanwhile, PGS- co -PCL-based samples and their nanocomposites demonstrated promising biocompatibility and antibacterial characteristics. Biodegradability experiments revealed that at pH 7, PGS- co -PCL-HA10% was degraded by 45% within 30 days, whereas at pH 11, degradation accelerated to 65%. This study’s findings provide a novel approach for soft tissue engineers to construct effective scaffolds with great biocompatibility and enhanced mechanical properties by combining PGS with co -PCL and adding HA nanoparticles.