Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

Diffuse midline gliomas (DMGs) are aggressive and fatal pediatric tumors of the central nervous system that are highly resistant to treatments. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, reshaping the epigenetic landscape of these cells to p...

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Bibliographic Details
Published in:eLife 2024-08, Vol.13
Main Authors: Algranati, Danielle, Oren, Roni, Dassa, Bareket, Fellus-Alyagor, Liat, Plotnikov, Alexander, Barr, Haim, Harmelin, Alon, London, Nir, Ron, Guy, Furth, Noa, Shema, Efrat
Format: Article
Language:English
Subjects:
Acetylation
Animal models
Animals
Antineoplastic Agents - pharmacology
Brain cancer
Brain tumors
Cell Line, Tumor
Cell Survival - drug effects
Cell viability
Central nervous system
Child
Disease Models, Animal
DMG
Drug therapy, Combination
Epigenetic inheritance
Epigenetics
Gene amplification
Glioma
Glioma - drug therapy
Glioma - genetics
Glioma - pathology
Glioma cells
Gliomas
Health aspects
Histone deacetylase
Histone Deacetylase Inhibitors - pharmacology
Histone Deacetylases - genetics
Histone Deacetylases - metabolism
Histone H3
Histones
Histones - genetics
Histones - metabolism
Humans
Lysine
Medical research
Medicine, Experimental
Methionine
Methylation
Mice
Myc protein
oncogene
Patients
Pediatrics
Pin1 protein
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Scientific equipment and supplies industry
TOR protein
Transcriptomes
Tumorigenesis
Tumors
Vorinostat
Vorinostat - pharmacology
Xenograft Model Antitumor Assays
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